Central Role of the EGF Receptor in Neurometabolic Aging英文文献资料.docVIP

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Central Role of the EGF Receptor in Neurometabolic Aging英文文献资料.doc

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Central Role of the EGF Receptor in Neurometabolic Aging英文文献资料

HindawiPublishingCorporation InternationalJournalofEndocrinology Volume2012,ArticleID739428,14pages doi:10.1155/2012/739428 ReviewArticle CentralRoleoftheEGFReceptorinNeurometabolicAging SanaSiddiqui, 1 MengFang, BinNi, DaoyuanLu, 1 1 1 andStuartMaudsley 1 BronwenMartin, 2 1 2 ReceptorPharmacologyUnit,NationalInstituteonAging,Baltimore,MD21224,USA MetabolismUnit,NationalInstituteonAging,Baltimore,MD21224,USA CorrespondenceshouldbeaddressedtoStuartMaudsley,maudsleyst@ Received30March2012;Accepted1May2012 AcademicEditor:HuanCai Copyright?2012SanaSiddiquietal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense, whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited. Astrongconnectionbetweenneuronalandmetabolichealthhasbeenrevealedinrecentyears.Itappearsthatbothnormaland pathophysiologicalaging,aswellasneurodegenerativedisorders,areallprofoundlyin?uencedbythis“neurometabolic”interface, thatis,communicationbetweenthebrainandmetabolicorgans.Animportantaspectofthis“neurometabolic”axisthatneeds tobeinvestigatedinvolvesanelucidationofmolecularfactorsthatknitthesetwofunctionalsignalingdomains,neuronaland metabolic,together.Thispaperattemptstoidentifyanddiscussapotentialkeystonesignalingfactorinthis“neurometabolic” axis,thatis,theepidermalgrowthfactorreceptor(EGFR).TheEGFRhasbeenpreviouslydemonstratedtoactasasignaling nexusformanyligandsignalingmodalitiesandcellularstressors,forexample,radiationandoxidativeradicals,linkedtoagingand degeneration.TheEGFRisexpressedinawidevarietyofcells/tissuesthatpertaintothecoordinatedregulationofneurometabolic activity.EGFRsignalinghasbeenhighlighteddirectlyorindirectlyinaspectrumofneurometabolicconditions,forexample, metabolicsyndrome,diabetes,Alzheimer’sdisease,cancer,andcardiorespiratoryfunction.Understandingthepositioningofthe EGFRwithintheneurometabolicdomainwillenhanceourappreciationoftheabilityofthisreceptorsystemtounderpinhighly complexp