Capsule Endoscopy in Celiac Disease英文文献资料.docVIP

HindawiPublishingCorporation GastroenterologyResearchandPractice Volume2012,ArticleID676073,5pages doi:10.1155/2012/676073 ReviewArticle CapsuleEndoscopyinCeliacDisease E.AkinandO.Ersoy DepartmentofGastroenterology,AnkaraAtaturkResearchandEducationHospital,06800Ankara,Turkey CorrespondenceshouldbeaddressedtoE.Akin,ebrudakin@ Received15July2011;Accepted26September2011 AcademicEditor:MarkEdwardMcAlindon Copyright?2012E.AkinandO.Ersoy. This is an open access article distributed under the Creative Commons Attribution License,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperly cited. Capsuleendoscopy(CE)hasbeenincreasinglyusedfordiagnosingdiseaseofthesmallbowel.Itisanattractivetechniquefor assessingceliacdisease(CD)becauseitisnoninvasiveandprovidesacloseandmagni?edviewofthemucosaoftheentiresmall bowel.TheaimofthispaperistoupdatethecurrentdataontheuseofCEfordiagnosingvillousatrophyandcomplicationsof CD. Celiac disease (CD) is a chronic autoimmune enteropathy occurring in genetically predisposed individuals following ingestion of wheat gluten and related protein fractions of othergrains[1].CDisthemostfrequentlyseenenteropathy in western countries, and its prevalence is 0.7–2% [2]. Patients present with diarrhea, weight loss, steatorrhea, or malnutrition syndromes such as anemia and diminished bonemassduetode?cienciesofimportantnutrients(iron, folate,calcium,andfat-solublevitamins)[3].However,the increasedinterestforthispathologyoverthelast2decades allowed diagnosing CD also in those with the silent or “atypical” form. These patients may present vague and subclinical manifestations such as dyspeptic symptoms or esophageal re?ux, irritable bowel syndrome, polyneuropa- thy,orironde?ciencyanemia[4].Theanalogyofaniceberg wassuggestedforCD,meaningthatonlyasmallportionof patientswith classicsymptomsarediagnosed,whereasthe majorityofasymptomaticindividualsorsubjectswithmild, nonspeci?c symptoms remain undiagnosed and untreated