Carbon Dioxide Insufflation in Colonoscopy Is Safe A Prospective Trial of 347 Patients英文文献资料.docVIP

Carbon Dioxide Insufflation in Colonoscopy Is Safe A Prospective Trial of 347 Patients英文文献资料.doc

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Carbon Dioxide Insufflation in Colonoscopy Is Safe A Prospective Trial of 347 Patients英文文献资料

HindawiPublishingCorporation DiagnosticandTherapeuticEndoscopy Volume2012,ArticleID692532,4pages doi:10.1155/2012/692532 ClinicalStudy CarbonDioxideInsuf?ationinColonoscopyIsSafe: AProspectiveTrialof347Patients M.Geyer, 1U.Guller,2,3andCh.Beglinger4 1 2 3 4 GastroenterologieWettingen,Rosengartenstrasse2,5430Wettingen,Switzerland DepartmentofOncology,Kantonsspital,9007St.Gallen,Switzerland DepartmentofVisceralSurgeryandMedicine,UniversityHospitalBern,3010Bern,Switzerland DepartmentofGastroenterology,UniversityHospital,4031Basel,Switzerland CorrespondenceshouldbeaddressedtoM.Geyer,geyer@gastroenterologie-wettingen.ch Received1June2012;Revised16August2012;Accepted29August2012 AcademicEditor:Jean-MarcDumonceau Copyright?2012M.Geyeretal. This is an open access article distributedunder the Creative Commons AttributionLicense, whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited. Available evidence suggests that the use of CO2 insu?ation in endoscopy is more comfortable for the patient. The safety of CO2useincolonoscopyremainscontentious,particularlyinsedatedpatients.Theobjectiveofthepresentprospectivetrialwas to assess the safety of CO2 colonoscopies. Methods. 109 patients from our previous randomized CO2 colonoscopy study and anadditional238subsequentconsecutiveunselectedpatientswhohadaroutinecolonoscopyperformedinaprivatepractice wereenrolledfromApril2008throughSeptember2008.Allbut2patientsweresedated.Allpatientswereroutinelymonitored withtranscutaneousCO2 measurement.VolumesofCO2 administeredwerecorrelatedwithcapnographicmeasurementsfrom transcutaneousmonitoring.Results.Ofthe347patientsexamined,57%werewomen;mean(SD)ageofparticipantswasof60.2 years(12.8).Meanpropofoldosagewas136mg(64mg).MeanCO2valueswere34.7mmHg(5.3)atbaseline,38.9mmHg(5.5) uponreachingtheileum,and36.9mmHg(5.0)atexamination’send.MeanmaximumincreaseofCO2 was4.5mmHg(3.6). NocorrelationwasobservedbetweenvolumeofCO2administeredandincreasein

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