Association Study of the β2-Adrenergic Receptor Gene Polymorphisms and Hypertension in the Northern Han Chinese 英文参考文献.docVIP

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Association Study of the β2-Adrenergic Receptor Gene Polymorphisms and Hypertension in the Northern Han Chinese 英文参考文献.doc

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Association Study of the β2-Adrenergic Receptor Gene Polymorphisms and Hypertension in the Northern Han Chinese 英文参考文献

AssociationStudyoftheb2-AdrenergicReceptorGene PolymorphismsandHypertensionintheNorthernHan Chinese YuqingLou1.,JielinLiu1.,YaoLi2,YaLiu1,ZuoguangWang1,KuoLiu1,HaiWu2,QiuliNiu1,WeiGu1, YanhongGuo3,ZhizhongLi4*,ShaojunWen1* 1Department of Hypertension Research, Beijing Anzhen Hospital, Capital Medical University and Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing, People’sRepublicofChina,2StateKeyLaboratoryofGeneticEngineering,InstituteofGenetics,SchoolofLifeSciences,FudanUniversity,Shanghai,People’sRepublicof China,3DepartmentofCardiology,PekingUniversityThirdHospital,Beijing,People’sRepublicofChina,4EmergencyCenterofHeart,LungandBloodVesselDiseases, BeijingAnzhenHospital,CapitalMedicalUniversity,Beijing,People’sRepublicofChina Abstract Background: The b2-adrenergic receptor (ADRB2) gene has been widely researched as a candidate gene for essential hypertension(EH),butnoconsensushasbeenreachedindifferentethnicities.Theaimofthepresentstudywastoevaluate thepossibleassociationbetweentheADRB2genepolymorphismsandtheEHriskintheNorthernHanChinesepopulation. Methodology/Principal Findings: This study included 747 hypertensive subjects and 390 healthy volunteers as control subjectsintheNorthernHanChinese.GenotypingwasperformedtoidentifytheC-47T,A46GandC79Gpolymorphismsof the ADRB2 gene. G allelic frequency of A46G polymorphism was significantly higher in hypertensive subjects (P=0.011, OR=1.287, 95%CI [1.059–1.565]) than that in controls. Significant association could also be found in dominant genetic model (GG+AG vs. AA, P=0.006, OR=1.497, 95%CI [1.121–1.998]), in homozygote comparison (GG vs. AA, P=0.025, OR=1.568, 95%CI [1.059–2.322]), and in additive genetic model (GG vs. AG vs. AA, P=0.012, OR=1.282, 95%CI [1.056– 1.555]).Subgroupanalysesperformedbygendersuggestedthatthisassociationcouldbefoundinmale,butnotinfemale. StratificationanalysesbyobesityshowedthatA46Gpolymorphismwasrelatedtotheprevalenceofhypertensioninthe obesepopulation(GGvs.AGvs.AA,P,0.0