Associations of Different Phenotypes of Wheezing Illness in Early Childhood with Environmental Variables Implicated in the Aetiology of Asthma 英文参考文献.docVIP

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Associations of Different Phenotypes of Wheezing Illness in Early Childhood with Environmental Variables Implicated in the Aetiology of Asthma 英文参考文献.doc

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Associations of Different Phenotypes of Wheezing Illness in Early Childhood with Environmental Variables Implicated in the Aetiology of Asthma 英文参考文献

AssociationsofDifferentPhenotypesofWheezingIllness inEarlyChildhoodwithEnvironmentalVariables ImplicatedintheAetiologyofAsthma RaquelGranell*,JonathanA.C.Sterne,JohnHenderson SchoolofSocialandCommunityMedicine,UniversityofBristol,Bristol,UnitedKingdom Abstract Rationale:Asthmaisacomplexheterogeneousdiseasethathasincreasedinprevalenceinmanyindustrialisedcountries. However, the causes of asthma inception remain elusive. Consideration of sub-phenotypes of wheezing may reveal importantcluestoaetiologicalriskfactors. Methods: Longitudinal phenotypes capturing population heterogeneity in wheezing reports from birth to 7 years were derived using latent class analysis in the Avon Longitudinal Study of Parents and Children (ALSPAC). Probability of class membership was used to examine the association between five wheezing phenotypes (transient early, prolonged early, intermediate-onset,late-onset,persistent)andearlyliferiskfactorsforasthma. Results: Phenotypes had similar patterns and strengths of associations with early environmental factors. Comparing transient early with prolonged early wheezing showed a similar pattern of association with most exposure variables consideredintermsofthedirectionoftheeffectestimatesbutwithprolongedearlywheezingtendingtohavestronger associationsthantransientearlywheezingexceptforparityanddaycareattendance. Conclusions: Associations with early life risk factors suggested that prolonged early wheeze might be a severe form of transient early wheezing. Although differences were found in the associations of early life risk factors with individual phenotypes,thesedidnotpointtonovelaetiologicalpathways.Persistentwheezingphenotypehasfeaturessuggesting overlapofearlyandlate-onsetphenotypes. Citation:GranellR,SterneJAC,HendersonJ(2012)AssociationsofDifferentPhenotypesofWheezingIllnessinEarlyChildhoodwithEnvironmentalVariables ImplicatedintheAetiologyofAsthma.PLoSONE7(10):e48359.doi:10.1371/journal.pone.0048359 Editor:D.WilliamCameron,UniversityofOtta