Associations of Serum 25-Hydroxyvitamin D, Parathyroid Hormone and Calcium with Cardiovascular Risk Factors Analysis of 3 NHANES Cycles (2001–2006) 英文参考文献.docVIP

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Associations of Serum 25-Hydroxyvitamin D, Parathyroid Hormone and Calcium with Cardiovascular Risk Factors Analysis of 3 NHANES Cycles (2001–2006) 英文参考文献.doc

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Associations of Serum 25-Hydroxyvitamin D, Parathyroid Hormone and Calcium with Cardiovascular Risk Factors Analysis of 3 NHANES Cycles (2001–2006) 英文参考文献

AssociationsofSerum25-HydroxyvitaminD,Parathyroid HormoneandCalciumwithCardiovascularRiskFactors: Analysisof3NHANESCycles(2001–2006) AbigailFraser*,DylanWilliams,DebbieA.Lawlor DepartmentofSocialMedicine,MedicalResearchCouncilCentreforCausalAnalysesinTranslationalEpidemiology,UniversityofBristol,Bristol,UnitedKingdom Abstract Background:Increasingevidencesuggestsaroleformineralmetabolismincardiovasculardiseaserisk.25-hydroxyvitaminD (25(OH)D),parathyroidhormone(PTH),andcalciummaybedirectlyassociatedwithcardiovascularriskfactorsormediated byeachother. Methodology/Principal Findings: We combined data for adult participants in three cycles of the National Health and Nutrition Examination Survey (2001–2, 2003–4, 2005–6), a representative sample of the civilian, non-institutionalized US population (N=3,958). Using this data we examined joint associations of 25(OH)D, PTH and calcium with a range of cardiovascularriskfactors.25(OH)Dwasinverselyassociatedwithfastinginsulin(meandifferenceininsulinper1standard deviation25(OH)D:20.053(95%CI:20.091,20.015)),glucose(20.04695%CI:20.081,20.012)andsystolicbloodpressure (SBP) (20.032 95%CI: 20.062, 20.001), and positively associated with high density lipoprotein cholesterol HDL-c (0.088 95%CI: 0.044, 0.148), after adjustment for ethnicity, smoking, socio-economic status and waist circumference. PTH was positivelyassociatedwithdiastolicbloodpressure(0.110,95%CI:0.055,0.164)inconfounderadjustedmodels,butwasnot associatedwithothercardiovascularriskfactors.Albuminadjustedcalciumwasassociatedwithtriglycerides(0.10295%CI: 0.063,0.141),postloadglucose(0.078,95%CI:0.025,0.130),fastinginsulin(0.074,95%CI:0.044,0.104),HbA1c(0.070,95%CI: 0.036, 0.105), SBP (0.064, 95%CI: 0.028, 0.100), fasting glucose (0.055, 95%CI: 0.018, 0.092) and low density lipoprotein cholesterol (0.052, 95%CI: 0.014, 0.091). With mutual adjustment for each other, these associations remained essentially unchanged. Conclusions/Significance: Lower levels of 25(OH)D and h