Bone T-Scores and Functional Status A Cross-Sectional Study on German Elderly 英文参考文献.docVIP

Bone T-Scores and Functional Status A Cross-Sectional Study on German Elderly 英文参考文献.doc

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Bone T-Scores and Functional Status A Cross-Sectional Study on German Elderly 英文参考文献

BoneT-ScoresandFunctionalStatus:ACross-Sectional StudyonGermanElderly ShomaBerkemeyer1*,JochenSchumacher2,UlrichThiem1,LudgerPientka1 1DepartmentofGeriatrics,UniversityofBochum,MarienhospitalHerne,Herne,Germany,2DepartmentofInternalMedicine,AlfriedKruppKrankenhausSteele,University ofDuisburg-Essen,Essen,Germany Abstract Background:WeexploretheassociationbetweenboneT-scores,usedinosteoporosisdiagnosis,andfunctionalstatussince wehypothesizedthatbonehealthcanimpactelderlyfunctionalstatusandindirectlyindependence. Methods:Inacross-sectionalstudy(2005–2006)oncommunitydwellingelderly(.=75years)fromHerne,Germanywe measured bone T-scores with Dual-energy X-ray Absorptiometry, and functional status indexed by five geriatric tests: activitiesofdailyliving,instrumentalactivitiesofdailyliving,testofdementia,geriatricdepressionscoreandthetimed-up- and-go test, and two pooled indexes: raw and standardized. Generalized linear regression was used to determine the relationshipbetweenT-scoresandfunctionalstatus. Results:From3243addresses,only632(19%)completedaclinicalvisit,ofwhichonly440(male:female,243:197)couldbe includedinanalysis.T-scores(20.99,95%confidenceinterval[CI],21.1–0.9)predictedactivitiesofdailyliving(95.3CI,94.5– 96.2), instrumental activities of daily living (7.3 CI, 94.5–96.2), and timed-up-and-go test (10.7 CI, 10.0–11.3) (P, =0.05). PooleddatashowedthataunitimprovementinT-scoreimprovedstandardizedpooledfunctionalstatus(15CI,14.7–15.3) by 0.41 and the raw (99.4 CI, 97.8–101.0) by 2.27 units. These results were limited due to pooling of different scoring directions,selectionbias,andaneedtofollow-upwithevidencetesting. Conclusions: T-scores associated with lower functional status in community-dwelling elderly. Regular screening of osteoporosisasapreventivestrategymighthelpmaintainlifequalitywithaging. Citation: Berkemeyer S, Schumacher J, Thiem U, Pientka L (2009) Bone T-Scores and Functional Status: A Cross-Sectional Study on German Elderly. PLoS ONE4(12):e8216.doi

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