Brain Morphological Signatures for Chronic Pain 英文参考文献.docVIP

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Brain Morphological Signatures for Chronic Pain 英文参考文献.doc

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Brain Morphological Signatures for Chronic Pain 英文参考文献

BrainMorphologicalSignaturesforChronicPain MarwanN.Baliki1,ThomasJ.Schnitzer2,WilliamR.Bauer3,A.VaniaApkarian1,4,5* 1DepartmentofPhysiology,NorthwesternUniversity, Chicago,Illinois,UnitedStatesofAmerica, 2DepartmentofPhysicalMedicineandRehabilitation,Northwestern University, Chicago, Illinois, United States of America, 3Department of Neuroscience, University of Toledo, Toledo, Ohio, United States of America, 4Department of Anesthesia,FeinbergSchoolofMedicine,Chicago,Illinois,UnitedStatesofAmerica,5DepartmentofSurgery,FeinbergSchoolofMedicine,Chicago,Illinois,UnitedStates ofAmerica Abstract Chronicpaincanbeunderstoodnotonlyasanalteredfunctionalstate,butalsoasaconsequenceofneuronalplasticity. HereweuseinvivostructuralMRItocompareglobal,local,andarchitecturalchangesingraymatterpropertiesinpatients suffering from chronic back pain (CBP), complex regional pain syndrome (CRPS) and knee osteoarthritis (OA), relative to healthycontrols.Wefindthatdifferentchronicpaintypesexhibituniqueanatomical‘brainsignatures’.OnlytheCBPgroup showedalteredwhole-braingraymattervolume,whileregionalgraymatterdensitywasdistinctforeachgroup.Voxel-wise comparisonofgraymatterdensityshowedthattheimpactontheextentofchronicityofpainwaslocalizedtoacommon setofregionsacross allconditions.WhengraymatterdensitywasexaminedforlargeregionsapproximatingBrodmann areas,itexhibiteduniquelarge-scaledistributednetworksforeachgroup.Wederivedabarcode,summarizedbyasingle index of within-subject co-variation of gray matter density, which enabled classification of individual brains to their conditions with high accuracy. This index also enabled calculating time constants and asymptotic amplitudes for an exponential increase in brain re-organization with pain chronicity, and showed that brain reorganization with pain chronicitywas6timesslowerandtwiceaslargeinCBPincomparisontoCRPS.Theresultsshowanexuberanceofbrain anatomicalreorganizationpeculiartoeachconditionandassuchreflectingtheuniquemaladaptivephysiologyofdif