Differences in Patient Age Distribution between Influenza A Subtypes 英文参考文献.docVIP

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Differences in Patient Age Distribution between Influenza A Subtypes 英文参考文献.doc

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Differences in Patient Age Distribution between Influenza A Subtypes 英文参考文献

DifferencesinPatientAgeDistributionbetween InfluenzaASubtypes HosseinKhiabanian1*,GregoryM.Farrell2,KirstenSt.George2,RaulRabadan1 1DepartmentofBiomedicalInformaticsandCenterforComputationalBiologyandBioinformatics,ColumbiaUniversityCollegeofPhysiciansandSurgeons,NewYork, NewYork,UnitedStatesofAmerica,2LaboratoryofViralDiseases,WadsworthCenter,NewYorkStateDepartmentofHealth,Albany,NewYork,UnitedStatesofAmerica Abstract Sincethespringof1977,twosubtypesofinfluenzaAvirus(H3N2andH1N1)havebeenseasonallyinfectingthehuman population. In this work we study the distribution of patient ages within the populations that exhibit the symptomatic disease caused by each of the different subtypes of seasonal influenza viruses. When the publicly available extensive information is pooled across multiple geographical locations and seasons, striking differences emerge between these subtypes.WereportthatthesymptomaticfluduetoH1N1isdistributedmainlyinayoungerpopulationrelativetoH3N2. (ThemedianageoftheH3N2patientsis23yearswhileH1N1patientsare9yearsold.)Thesedistinctcharacteristicspectra ofagegroups,possiblycarriedoverfrompreviouspandemics,areconsistentwithpreviousreportsfromvariousregional populationstudiesandalsofindingsontheevolutionarydynamicsofeachsubtype.Moreover,theyarerelevanttoage- relatedriskassessments,modelingofepidemiologicalnetworksforspecificagegroups,andage-specificvaccinedesign. Recently, a novel H1N1 virus has spread around the world. Preliminary reports suggest that this new strain causes symptomaticdiseaseintheyoungerpopulationinasimilarfashiontotheseasonalH1N1strains. Citation:KhiabanianH,FarrellGM,St.GeorgeK,RabadanR(2009)DifferencesinPatientAgeDistributionbetweenInfluenzaASubtypes.PLoSONE4(8):e6832. doi:10.1371/journal.pone.0006832 Editor:Genevie`veChe?ne,INSERM,France ReceivedMay22,2009;AcceptedAugust2,2009;PublishedAugust31,2009 Copyright: ?2009Khiabanianetal.Thisisanopen-access articledistributedunder thetermsoftheCreativeCommonsAttributionLicense,whichperm