Dissociation between Brain Amyloid Deposition and Metabolism in Early Mild Cognitive Impairment 英文参考文献.docVIP

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Dissociation between Brain Amyloid Deposition and Metabolism in Early Mild Cognitive Impairment 英文参考文献.doc

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Dissociation between Brain Amyloid Deposition and Metabolism in Early Mild Cognitive Impairment 英文参考文献

DissociationbetweenBrainAmyloidDepositionand MetabolisminEarlyMildCognitiveImpairment LiyongWu1,2,3,JaredRowley1,2,SaraMohades1,2,AntoineLeuzy1,2,MarinaTedeschiDauar1,2 , MonicaShin1,2,VladimirFonov4,JianpingJia3,SergeGauthier2,PedroRosa-Neto1,2,4*,theAlzheimer’s DiseaseNeuroimagingInitiative 1TranslationalNeuroimagingLaboratory,DouglasHospital,McGillUniversity,Montreal,Quebec,Canada,2McGillCentreforStudiesinAging,McGillUniversity,Montreal, Quebec, Canada, 3Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, China, 4McConnell Brain Imaging Centre, Montreal Neurological Institute,McGillUniversity,Montreal,Quebec,Canada Abstract Background: The hypothetical model of dynamic biomarkers for Alzheimer’s disease (AD) describes high amyloid depositionandhypometabolismatthemildcognitiveimpairment(MCI)stage.However,itremainsunknownwhetherbrain amyloidosisandhypometabolismfollowthesametrajectoriesinMCIindividuals.WeusedtheconceptofearlyMCI(EMCI) and late MCI (LMCI) as defined by the Alzheimer’s disease Neuroimaging Initiative (ADNI)-Go in order to compare the biomarkerprofilebetweenEMCIandLMCI. Objectives:Toexaminetheglobalandvoxel-basedneocorticalamyloidburdenandmetabolismamongindividualswhoare cognitivelynormal(CN),aswellasthosewithEMCI,LMCIandmildAD. Methods:Inthepresentstudy,354participants,includingCN(n=109),EMCI(n=157),LMCI(n=39)andAD(n=49),were enrolledbetweenSeptember2009andNovember2011throughADNI-GOandADNI-2.Brainamyloidloadandmetabolism wereestimatedusing[18F]AV45and[18F]fluorodeoxyglucose([18F]FDG)PET,respectively.Uptakeratioimagesof[18F]AV45 and [18F]FDG were calculated by dividing the summed PET image by the median counts of the grey matter of the cerebellumandpons,respectively.Groupdifferencesofglobal[18F]AV45and[18F]FDGwereanalyzedusingANOVA,while thevoxel-basedgroupdifferenceswereestimatedusingstatisticparametricmapping(SPM). Results: EMCIpatients showedhigher global[18F]AV45 retentioncomparedtoCNandloweruptakecomparedtoLMCI. SPMd