Effects of Naltrexone on Pain Sensitivity and Mood in Fibromyalgia No Evidence for Endogenous Opioid Pathophysiology 英文参考文献.docVIP

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Effects of Naltrexone on Pain Sensitivity and Mood in Fibromyalgia No Evidence for Endogenous Opioid Pathophysiology 英文参考文献.doc

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Effects of Naltrexone on Pain Sensitivity and Mood in Fibromyalgia No Evidence for Endogenous Opioid Pathophysiology 英文参考文献

EffectsofNaltrexoneonPainSensitivityandMoodin Fibromyalgia:NoEvidenceforEndogenousOpioid Pathophysiology JarredW.Younger1*,AlexJ.Zautra2,EricT.Cummins3 1DepartmentofAnesthesia,StanfordUniversitySchoolofMedicine,PaloAlto,California,UnitedStatesofAmerica,2DepartmentofPsychology,ArizonaStateUniversity, Tempe,Arizona,UnitedStatesofAmerica,3CollegeofMedicine,UniversityofArizona,Tucson,Arizona,UnitedStatesofAmerica Abstract The pathophysiological mechanisms underlying fibromyalgia are still unknown, although some evidence points to endogenousopioiddysfunction.Weexaminedhowendogenousopioidantagonismaffectspainandmoodforwomenwith andwithoutfibromyalgia.Tenwomenwithfibromyalgiaandtenage-andgender-matched,healthycontrolseachattended twolaboratorysessions.Eachparticipantreceivednaltrexone(50mg)atonesession,andplaceboattheothersession,ina randomizedanddouble-blindfashion.Participantsweretestedforchangesinsensitivitytoheat,cold,andmechanicalpain. Additionally,wecollectedmeasuresofmoodandopioidwithdrawalsymptomsduringthelaboratorysessionsandathome thenightfollowingeachsession.Atbaseline,thefibromyalgiagroupexhibitedmoresomaticcomplaints,greatersensory sensitivity,moreopioidwithdrawalsomaticsymptoms,andlowermechanicalandcoldpain-tolerancethandidthehealthy controlgroup.Neithergroupexperiencedchangesinpainsensitivityduetonaltrexoneadministration.Naltrexonedidnot differentiallyaffectself-reportedwithdrawalsymptoms,ormood,inthefibromyalgiaandcontrolgroups.Consistentwith priorresearch,therewasnoevidencefoundforabnormalendogenousopioidactivityinwomenwithfibromyalgia. Citation:YoungerJW,ZautraAJ,CumminsET(2009)EffectsofNaltrexoneonPainSensitivityandMoodinFibromyalgia:NoEvidenceforEndogenousOpioid Pathophysiology.PLoSONE4(4):e5180.doi:10.1371/journal.pone.0005180 Editor:WilliamTaylor,UniversityofOtago,NewZealand ReceivedJanuary29,2009;AcceptedMarch16,2009;PublishedApril13,2009 Copyright: ? 2009 Younger et al. This is an open-access article distributed under the terms of the Creative Com