Effects of Pre-Meal Drinks with Protein and Amino Acids on Glycemic and Metabolic Responses at a Subsequent Composite Meal 英文参考文献.docVIP

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Effects of Pre-Meal Drinks with Protein and Amino Acids on Glycemic and Metabolic Responses at a Subsequent Composite Meal 英文参考文献.doc

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Effects of Pre-Meal Drinks with Protein and Amino Acids on Glycemic and Metabolic Responses at a Subsequent Composite Meal 英文参考文献

EffectsofPre-MealDrinkswithProteinandAminoAcids onGlycemicandMetabolicResponsesataSubsequent CompositeMeal UlrikaJ.Gunnerud1*,CorneliaHeinzle1,JensJ.Holst2,ElinM.Ostman¨ 1,IngerM.E.Bjo¨rck1 1Department of Applied Nutrition and Food Chemistry, Lund University, Lund, Sweden, 2Department of Medical Physiology, The Panum Institute, University of Copenhagen,Copenhagen,Denmark Abstract Background:Wheyproteinshaveinsulinogenicpropertiesandtheeffectappearstooriginatefromaspecificpostprandial plasmaaminoacidpattern.Theinsulinogeniceffectcanbemimickedbyaspecificmixtureofthefiveaminoacidsiso,leu, lys,thrandval. Objective:Theobjectivewastoevaluatetheefficacyofpre-mealbolusesofwheyorsoyproteinwithorwithoutadded amino acids on glycaemia, insulinemia as well as on plasma responses of incretins and amino acids at a subsequent compositemeal.Additionally,plasmaghrelinandsubjectiveappetiteresponseswerestudied. Design:Inrandomizedorder,fourteenhealthyvolunteerswereservedastandardizedcompositehamsandwichmealwith either water provided (250ml) during the time course of the meal, or different pre-meal protein drinks (PMPD) (100ml providedasabolus)withadditionalwater(150ml)servedtothemeal.ThePMPDscontained9gproteinandwerebased oneitherwheyorsoyproteinisolates,withorwithoutadditionofthefiveaminoacids(iso,leu,lys,thrandval)orthefive aminoacids+arg. Results:AllPMPDmealssignificantlyreducedincrementalareaforplasmaglucoseresponse(iAUC)duringthefirst60min. AllwheybasedPMPDmealsdisplayedlowerglycemicindicescomparedtothereferencemeal.Therewerenosignificant differencesfortheinsulinemicindices.Theearlyinsulinresponse(iAUC0–15min)correlated positivelytoplasma amino acids,GIPandGLP-1aswellastotheglycemicprofile.Additionally,inversecorrelationswerefoundbetweeninsuliniAUC0– 15minandtheglucosepeak. Conclusion: The data suggests that a pre-meal drink containing specific proteins/amino acids significantly reduces postprandial glycemia following a composite meal, in absence of elevate