Efficacy of Praziquantel against Schistosoma mekongi and Opisthorchis viverrini A Randomized, Single-Blinded Dose-Comparison Trial 英文参考文献.docVIP

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Efficacy of Praziquantel against Schistosoma mekongi and Opisthorchis viverrini A Randomized, Single-Blinded Dose-Comparison Trial 英文参考文献.doc

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Efficacy of Praziquantel against Schistosoma mekongi and Opisthorchis viverrini A Randomized, Single-Blinded Dose-Comparison Trial 英文参考文献

EfficacyofPraziquantelagainstSchistosomamekongi andOpisthorchisviverrini:ARandomized,Single- BlindedDose-ComparisonTrial LeonoreLovis1.,TippiK.Mak2,3.,KhamphengPhongluxa2,3,4,PhonepasongAye′ Soukhathammavong2,3,4,YouthanavanhVonghachack2,3,5,JenniferKeiser3,6,PenelopeVounatsou2,3 MarcelTanner2,3,ChristophHatz3,7,8,Ju¨rgUtzinger2,3,PeterOdermatt2,3*,KongsapAkkhavong4 , 1LaboratoryofParasitology,UniversityofNeucha?tel,Neucha?tel,Switzerland,2DepartmentofEpidemiologyandPublicHealth,SwissTropicalandPublicHealthInstitute, Basel,Switzerland,3UniversityofBasel,Basel,Switzerland,4NationalInstituteofPublicHealth,Vientiane,LaoPeople’sDemocraticRepublic,5ParasitologyUnit,Faculty ofBasicSciences,UniversityofHealthSciences,Vientiane,LaoPeople’sDemocraticRepublic,6DepartmentofMedicalParasitologyandInfectionBiology,SwissTropical andPublicHealthInstitute,Basel,Switzerland,7DepartmentofMedicalServicesandDiagnostic,SwissTropicalandPublicHealthInstitute,Basel,Switzerland,8Institute ofSocialandPreventiveMedicine,UniversityofZurich,Zurich,Switzerland Abstract Background:SchistosomiasisandopisthorchiasisareofpublichealthimportanceinSoutheastAsia.Praziquantel(PZQ)is thedrugofchoiceformorbiditycontrolbutfewdosecomparisonshavebeenmade. Methodology: Ninety-three schoolchildren were enrolled in an area of Lao PDR where Schistosoma mekongi and OpisthorchisviverrinicoexistforaPZQdose-comparisontrial.Prevalenceandintensityofinfectionsweredeterminedbya rigorous diagnostic effort (3 stool specimens, each examined with triplicate Kato-Katz) before and 28–30 days after treatment. Ninety children with full baseline data were randomized to receive PZQ: the 40mg/kg standard single dose (n=45) or a 75mg/kg total dose (50mg/kg+25mg/kg, 4hours apart; n=45). Adverse events were assessed at 3 and 24hoursposttreatment. Principal Findings: Baseline infection prevalence of S. mekongi and O. viverrini were 87.8% and 98.9%, respectively. S. mekongicurerateswere75.0%(95%confidenceinterval(CI):56.6–88.5%)and80