Efficacy of a Non-Hypercalcemic Vitamin-D2 Derived Anti-Cancer Agent (MT19c) and Inhibition of Fatty Acid Synthesis in an Ovarian Cancer Xenograft Model 英文参考文献.docVIP

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Efficacy of a Non-Hypercalcemic Vitamin-D2 Derived Anti-Cancer Agent (MT19c) and Inhibition of Fatty Acid Synthesis in an Ovarian Cancer Xenograft Model 英文参考文献.doc

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Efficacy of a Non-Hypercalcemic Vitamin-D2 Derived Anti-Cancer Agent (MT19c) and Inhibition of Fatty Acid Synthesis in an Ovarian Cancer Xenograft Model 英文参考文献

EfficacyofaNon-HypercalcemicVitamin-D2Derived Anti-CancerAgent(MT19c)andInhibitionofFattyAcid SynthesisinanOvarianCancerXenograftModel RichardG.Moore1,ThiloS.Lange1,KatinaRobinson1,KyuK.Kim1,AlperUzun2,TimothyC.Horan1, NadaKawar1,NaohiroYano3,SharonR.Chu4,QuanfuMao4,LaurentBrard5,MoniqueE.DePaepe4, JamesF.Padbury2,LeggyA.Arnold6,AlexanderBrodsky7,Tun-LiShen8,RakeshK.Singh1* 1 Molecular Therapeutics Laboratory, Program in Women’s Oncology, Department of Obstetrics and Gynecology, Women and Infants’ Hospital of Rhode Island, Alpert Medical School, Brown University, Providence, Rhode Island, United States of America,2 Center for Computational Molecular Biology, Department of Pediatrics, Women and Infants’ Hospital of Rhode Island, Alpert Medical School, Brown University, Providence, Rhode Island, United States of America,3 Department of Pediatrics, Women and Infants’ Hospital of Rhode Island, Alpert Medical School, Brown University, Providence, Rhode Island, United States of America,4 Developmental Pathology, Women and Infants’ Hospital of Rhode Island, Alpert Medical School, Brown University, Providence, Rhode Island, United States of America,5 Gynecology Oncology, Southern Illinois Medical School, Springfield, Illinois, United States of America, 6 Chemistry and Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, United States of America, 7 Department of Biology and Medicine, Brown University, Providence, Rhode Island, United States of America, 8 Department of Chemistry, Brown University, Providence, Rhode Island, United States of America Abstract Background: Numerous vitamin-D analogs exhibited poor response rates, high systemic toxicities and hypercalcemia in human trials to treat cancer. We identified the first non-hypercalcemic anti-cancer vitamin D analog MT19c by altering the A-ring of ergocalciferol. This study describes the therapeuti