Elevated Plasma IL-6 Associates with Increased Risk of Advanced Fibrosis and Cholangiocarcinoma in Individuals Infected by Opisthorchis viverrini 英文参考文献.docVIP

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Elevated Plasma IL-6 Associates with Increased Risk of Advanced Fibrosis and Cholangiocarcinoma in Individuals Infected by Opisthorchis viverrini 英文参考文献.doc

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Elevated Plasma IL-6 Associates with Increased Risk of Advanced Fibrosis and Cholangiocarcinoma in Individuals Infected by Opisthorchis viverrini 英文参考文献

ElevatedPlasmaIL-6AssociateswithIncreasedRiskof AdvancedFibrosisandCholangiocarcinomain IndividualsInfectedbyOpisthorchisviverrini BanchobSripa1,BanditThinkhamrop2,EimornMairiang3,ThewarachLaha4,SasithornKaewkes4, PaiboonSithithaworn4,MariaVictoriaPeriago5,VajarabhongsaBhudhisawasdi6,7, PonlapatYonglitthipagon1,8,JasonMulvenna8,PaulJ.Brindley9,AlexLoukas8,JeffreyM.Bethony5,9* 1DepartmentofPathology,KhonKaenUniversitySchoolofMedicine,KhonKaen,Thailand,2DepartmentofEpidemiologyandBiostatistics,KhonKaenUniversitySchool ofPublicHealth,KhonKaen,Thailand,3DepartmentofRadiology,KhonKaenUniversitySchoolofMedicine,KhonKaen,Thailand,4DepartmentofParasitology,Khon KaenUniversitySchoolofMedicine,KhonKaen,Thailand,5InstitutoRene′ Rachou,BeloHorizonte,MinasGerais,Brazil,6DepartmentofSurgery,KhonKaenUniversity School of Medicine, Khon Kaen, Thailand, 7Liver Fluke and Cholangiocarcinoma Research Center, Khon Kaen University, Khon Kaen, Thailand, 8Queensland Tropical HealthAlliance,JamesCookUniversity,Cairns,Queensland,Australia,9DepartmentofMicrobiology,ImmunologyTropicalMedicine,GeorgeWashingtonUniversity MedicalCenter,Washington,D.C.,UnitedStatesofAmerica Abstract Opisthorchisviverriniisconsideredamongthemostimportantofthefood-bornetrematodesduetoitsstrongassociation with advanced periductal fibrosis and bile duct cancer (cholangiocarcinoma). We investigated the relationship between plasma levels of Interleukin (IL)-6 and the risk of developing advanced fibrosis and bile duct cancer from chronic Opisthorchis infection. We show that IL-6 circulates in plasma at concentrations 58 times higher in individuals with advancedfibrosisthanage,sex,andnearest-neighbormatchedcontrolsand221timeshigherinindividualswithbileduct cancer than controls. We also observed a dose-response relationship between increasing levels of plasma IL-6 and increasingriskofadvancedfibrosisandbileductcancer;forexample,inageandsexadjustedanalyses,individualswiththe highest quartiles of plasma IL-6 had a 19 t