Efficient Generation of iPS Cells from Skeletal Muscle Stem Cells 英文参考文献.docVIP

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Efficient Generation of iPS Cells from Skeletal Muscle Stem Cells 英文参考文献.doc

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Efficient Generation of iPS Cells from Skeletal Muscle Stem Cells 英文参考文献

EfficientGenerationofiPSCellsfromSkeletalMuscle StemCells KahYongTan1,2,3,4,SarahEminli2,3,5,6,SimoneHettmer1,2,3,7,KonradHochedlinger2,3,5,8,AmyJ. Wagers1,2,3,8 * 1SectiononIsletCellandRegenerativeBiology,JoslinDiabetesCenter,Boston,Massachusetts,UnitedStatedofAmerica,2DepartmentofStemCellandRegenerative Biology,HarvardUniversity, Cambridge,Massachusetts,UnitedStatedofAmerica,3HarvardStemCellInstitute,Cambridge,Massachusetts,UnitedStatedofAmerica, 4Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts, United Stated of America, 5Massachusetts General Hospital Cancer CenterandCenterforRegenerativeMedicine,Boston,Massachusetts,UnitedStatedofAmerica,6DepartmentofBiology,ChemistryandPharmacy,FreeUniversityof Berlin,Berlin,Germany,7DepartmentofPediatricOncology,DanaFarberCancerInstituteandDivisionofPediatricHematology/Oncology,Children’sHospital,Boston, Massachusetts,UnitedStatedofAmerica,8HowardHughesMedicalInstitute,ChevyChase,Maryland,UnitedStatesofAmerica Abstract Reprogramming of somatic cells into inducible pluripotent stem cells generally occurs at low efficiency, although what limitsreprogrammingofparticularcelltypesispoorlyunderstood.Recentdatasuggestthatthedifferentiationstatusofthe celltargetedforreprogrammingmayinfluenceitssusceptibilitytoreprogrammingaswellasthedifferentiationpotentialof theinducedpluripotentstem(iPS)cellsthatarederivedfromit.Toassessdirectlytheinfluenceoflineagecommitmenton iPScellderivationanddifferentiation,weevaluatedreprogramminginadultstemcellandmaturecellpopulationsresiding in skeletal muscle. Our data using clonal assays and asecond-generation inducible reprogramming system indicate that stem cells found in mouse muscle, including resident satellite cells and mesenchymal progenitors, reprogram with significantlygreaterefficiencythantheirmoredifferentiateddaughters(myoblastsandfibroblasts).However,incontrastto previous reports, we find no evidence of biased differentiation potential among iPS c