Effects of Long and Short Carboxylated or Aminated Multiwalled Carbon Nanotubes on Blood Coagulation 英文参考文献.docVIP

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Effects of Long and Short Carboxylated or Aminated Multiwalled Carbon Nanotubes on Blood Coagulation 英文参考文献.doc

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Effects of Long and Short Carboxylated or Aminated Multiwalled Carbon Nanotubes on Blood Coagulation 英文参考文献

EffectsofLongandShortCarboxylatedorAminated MultiwalledCarbonNanotubesonBloodCoagulation JieMeng.,XuelianCheng.,JianLiu,WeiqiZhang,XiaojinLi,HuaKong,HaiyanXu* InstituteofBasicMedicalSciences,ChineseAcademyofMedicalSciencesPekingUnionMedicalCollege,Beijing,People’sRepublicofChina Abstract Inthisworktheeffectsoffourdifferentmultiwalledcarbonnanotubes(MWCNTs),includinglongcarboxylated(L-COOH), shortcarboxylated(S-COOH),longaminated(L-NH2)andshortaminated(S-NH2)ones,ontheintegrityofredbloodcells, coagulation kinetics and activation of platelets were investigated with human whole blood. We found that the four MWCNTsinduceddifferentdegreesofredbloodcelldamageaswellasamildlevelofplateletactivation(10–25%).L-COOH and L-NH2 induced a higher level of platelet activation than S-COOH and S-NH2 respectively; meanwhile L-NH2 caused markedreductionsinplateletviability.ThepresenceofthefourMWCNTsledtoearlierfibrinformation,L-NH2increasedthe clotshardnesssignificantly,whileL-COOHandS-NH2madetheclotsbecomesofter.ItwasconcludedthatthefourMWCNTs affectedbloodcoagulationprocessandtheclotsmechanicalproperties;theyalsoalteredtheintegrityoftheredbloodcells andtheviabilityoftheplatelets,aswellasinducedplateletsactivation.TheeffectsofMWCNTsdependedonthesizeand chemistryofthenanotubesandthetypeofcellstheycontacted. Citation: Meng J,Cheng X,Liu J,Zhang W, LiX, et al. (2012) Effects ofLong and ShortCarboxylated orAminated MultiwalledCarbonNanotubeson Blood Coagulation.PLoSONE7(7):e38995.doi:10.1371/journal.pone.0038995 Editor:WilburLam,EmoryUniversity/GeorgiaInsitituteofTechnology,UnitedStatesofAmerica ReceivedFebruary23,2012;AcceptedMay17,2012;PublishedJuly10,2012 Copyright: ? 2012 Meng et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited. Funding:TheauthorsthankNationalKeyProgramofChina(973program2011CB933504),NationalNat