Endomyocardial Fibrosis Still a Mystery after 60 Years 英文参考文献.docVIP

Review EndomyocardialFibrosis:StillaMysteryafter60Years GeneBukhman1*,JohnZiegler2,EldrydParry3 1DivisionofSocialMedicineandHealthInequalities,BrighamandWomen’sHospital,Boston,Massachusetts,UnitedStatesofAmerica,2CancerRiskProgram,University ofCaliforniaSanFrancisco,SanFrancisco,California,UnitedStatesofAmerica,3ClinicalResearchUnit,LondonSchoolofHygieneTropicalMedicine,London,United Kingdom and the endocarditis parietalis fibroplastica that Wilhelm Lo¨ffler and othershaddescribedinEuropeinthesettingofhypereosinophilic Abstract: The pathologist Jack N. P. Davies identified endomyocardial fibrosis in Uganda in 1947. Since that time, reports of this restrictive cardiomyopathy have comefromotherpartsoftropicalAfrica,SouthAsia,and syndromes[19,20].Theeosinophilhypothesis—dominantthough still not well tested—has failed to convince critics who point to other plausible alternatives [21,22,23,24]. In fact, none of the SouthAmerica.InKampala,thediseaseaccountsfor20% etiologiccategoriesfirstmentionedbyWilliams,Ball,andDavies of heart disease patients referred for echocardiography. in1954haveleftthetableofpossiblecauses(Table1)[25]. We conducted a systematic review of research on the Despite uncertainty as to the cause of EMF, the volume of epidemiologyandetiologyofendomyocardialfibrosis.We reliedprimarilyonarticlesintheMEDLINEdatabasewith either ‘‘endomyocardial fibrosis’’ or ‘‘endomyocardial publications on the subject has declined during the past decade (Figure2).Inanefforttorekindleinterestinthisneglecteddisease, sclerosis’’ in the title. The volume of publications on endomyocardial fibrosis has declined since the 1980s. Despite several hypotheses regarding cause, no account of the etiology of this disease has yet fully explained its uniquegeographicaldistribution. we have undertaken a systematic review of research on this condition.Wehavebasedthisreviewprimarilyonarticlesinthe MEDLINE database published between January 1, 1950 and January 1, 2007 with either ‘‘endomy