Elevated Stress-Hemoconcentration in Major Depression Is Normalized by Antidepressant Treatment Secondary Analysis from a Randomized, Double-Blind Clinical Trial and Relevance to Cardiovascular Disease Risk 英文参考文献.docVIP

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Elevated Stress-Hemoconcentration in Major Depression Is Normalized by Antidepressant Treatment Secondary Analysis from a Randomized, Double-Blind Clinical Trial and Relevance to Cardiovascular Disease Risk 英文参考文献.doc

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Elevated Stress-Hemoconcentration in Major Depression Is Normalized by Antidepressant Treatment Secondary Analysis from a Randomized, Double-Blind Clinical Trial and Relevance to Cardiovascular Disease Risk 英文参考文献

ElevatedStress-HemoconcentrationinMajorDepression IsNormalizedbyAntidepressantTreatment:Secondary AnalysisfromaRandomized,Double-BlindClinicalTrial andRelevancetoCardiovascularDiseaseRisk Ma-LiWong1*,ChuanhuiDong1,KarinEsposito1,SarikaThakur2,WeiqingLiu3,RobertM.Elashoff3 ,Julio Licinio1 1Department of Psychiatry and Behavioral Sciences, Leonard M. Miller School of Medicine at the University of Miami, Miami, Florida, United States of America, 2DepartmentofPsychiatryandBiobehavioralSciences,DavidGeffenSchoolofMedicineatUniversityofCaliforniaLosAngeles,LosAngeles,California,UnitedStatesof America,3DepartmentofBiomathematics,UniversityofCaliforniaLosAngeles,LosAngeles,California,UnitedStatesofAmerica Abstract Background:Majordepressivedisorder(MDD)isanindependentriskfactorforcardiovasculardisease(CVD);thepresence of MDD symptoms in patients with CVD is associated with a higher incidence of cardiac complications following acute myocardial infarction (MI). Stress-hemoconcentration, a result of psychological stress that might be a risk factor for the pathogenesisofCVD,hasbeenstudiedinstress-challengeparadigmsbuthasnotbeensystematicallystudiedinMDD. Methods:Secondaryanalysisofstresshemoconcentrationwasperformedondatafromcontrolsandsubjectswithmildto moderateMDDparticipatinginanongoingpharmacogeneticstudyofantidepressanttreatmentresponsetodesipramine or fluoxetine. Hematologic and hemorheologic measures of stress-hemoconcentration included blood cell counts, hematocrit,hemoglobin,totalserumprotein,andalbumin,andwholebloodviscosity. Findings: Subjects with mild to moderate MDD had significantly increased hemorheologic measures of stress- hemoconcentrationandbloodviscositywhencomparedtocontrols;thesemeasureswerecorrelatedwithdepressionseverity. Measures of stress-hemoconcentration improved significantly after 8 weeks of antidepressant treatment. Improvements in whitebloodcellcount,redbloodcellmeasuresandplasmavolumewerecorrelatedwithdecreasedseverityofdepression. Conclusi