Efficient Network Reconstruction from Dynamical Cascades Identifies Small-World Topology of Neuronal Avalanches 英文参考文献.docVIP
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Efficient Network Reconstruction from Dynamical Cascades Identifies Small-World Topology of Neuronal Avalanches 英文参考文献
EfficientNetworkReconstructionfromDynamical
CascadesIdentifiesSmall-WorldTopologyofNeuronal
Avalanches
SinisaPajevic1,DietmarPlenz2*
1MathematicalandStatisticalComputingLaboratory,DivisionofComputationalBioscience,CenterforInformationTechnology,NationalInstitutesofHealth,Bethesda,
Maryland,UnitedStatesofAmerica,2SectiononCriticalBrainDynamics,LaboratoryofSystemsNeuroscience,NationalInstituteofMentalHealth,NationalInstitutesof
Health,Bethesda,Maryland,UnitedStatesofAmerica
Abstract
Cascadingactivityiscommonlyfoundincomplexsystemswithdirectedinteractionssuchasmetabolicnetworks,neuronal
networks, or disease spreading in social networks. Substantial insight into a system’s organization can be obtained by
reconstructing the underlying functional network architecture from the observed activity cascades. Here we focus on
Bayesian approaches and reduce their computational demands by introducing the Iterative Bayesian (IB) and Posterior
WeightedAveraging(PWA)methods.WeintroduceaspecialcaseofPWA,castinnonparametricform,whichwecallthe
normalizedcount(NC)algorithm.NCefficientlyreconstructsrandomandsmall-worldfunctionalnetworktopologiesand
architectures from subcritical, critical, and supercritical cascading dynamics and yields significant improvements over
commonly used correlation methods. With experimental data, NC identified a functional and structural small-world
topologyanditscorrespondingtrafficincorticalnetworkswithneuronalavalanchedynamics.
Citation: PajevicS,PlenzD(2009)Efficient Network Reconstruction fromDynamicalCascadesIdentifiesSmall-WorldTopologyofNeuronalAvalanches.PLoS
ComputBiol5(1):e1000271.doi:10.1371/journal.pcbi.1000271
Editor:OlafSporns,IndianaUniversity,UnitedStatesofAmerica
ReceivedJuly21,2008;AcceptedDecember10,2008;PublishedJanuary30,2009
Thisisanopen-accessarticledistributedunderthetermsoftheCreativeCommonsPublicDomaindeclarationwhichstipulatesthat,onceplacedinthepublic
domain,thisworkmaybefreelyreproduced,distributed,transmitted,modified,builtup
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