Estimating the Non-Monetary Burden of Neurocysticercosis in Mexico 英文参考文献.docVIP

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Estimating the Non-Monetary Burden of Neurocysticercosis in Mexico 英文参考文献.doc

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Estimating the Non-Monetary Burden of Neurocysticercosis in Mexico 英文参考文献

EstimatingtheNon-MonetaryBurdenof NeurocysticercosisinMexico RachanaBhattarai1,ChristineM.Budke1*,He′le`neCarabin2,JeffersonV.Proan?o3,JoseFlores-Rivera4, TeresaCorona4,RenataIvanek1,KarenF.Snowden5,AnaFlisser6 1DepartmentofVeterinaryIntegrativeBiosciences,CollegeofVeterinaryMedicine,TexasAMUniversity,CollegeStation,Texas,UnitedStatesofAmerica,2Department of Biostatistics and Epidemiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America, 3Hospital de Especialidades, CentroMe′dicoNacionalSigloXXI,InstitutoMexicanodelSeguroSocial,Me′xicoDistritoFederal,Mexico,4ClinicalLaboratoryofNeurodegenerativeDiseases,National InstituteofNeurologyandNeurosurgery,Me′xicoDistritoFederal,Mexico,5DepartmentofVeterinaryPathobiology,CollegeofVeterinaryMedicine,TexasAMUniversity, CollegeStation,Texas,UnitedStatesofAmerica,6FacultaddeMedicina,UniversidadNacionalAuto′nomadeMe′xico (UNAM),Me′xicoDistritoFederal,Mexico Abstract Background: Neurocysticercosis (NCC) is a major public health problem in many developing countries where health education,sanitation,andmeatinspectioninfrastructureareinsufficient.Theconditionoccurswhenhumansingesteggsof theporktapewormTaeniasolium,whichthendevelopintolarvaeinthecentralnervoussystem.AlthoughNCCisendemic inmanyareasoftheworldandisassociatedwithconsiderablesocio-economiclosses,theburdenofNCCremainslargely unknown.Thisstudyprovidesthefirstestimateofdisabilityadjustedlifeyears(DALYs)associatedwithNCCinMexico. Methods:DALYslostforsymptomaticcasesofNCCinMexicowereestimatedbyincorporatingmorbidityandmortalitydue to NCC-associated epilepsy, and morbidity due to NCC-associated severe chronic headaches. Latin hypercube sampling methodswereemployedtosamplethedistributionsofuncertainparametersandtoestimate95%credibleregions(95% CRs). Findings: In Mexico, 144,433 and 98,520 individuals are estimated to suffer from NCC-associated epilepsy and NCC- associatedseverechronicheadaches,respectively.Atotalof25,341