Evaluation of Social and Physical Enrichment in Modulation of Behavioural Phenotype in C57BL6J Female Mice 英文参考文献.docVIP

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Evaluation of Social and Physical Enrichment in Modulation of Behavioural Phenotype in C57BL6J Female Mice 英文参考文献.doc

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Evaluation of Social and Physical Enrichment in Modulation of Behavioural Phenotype in C57BL6J Female Mice 英文参考文献

EvaluationofSocialandPhysicalEnrichmentin ModulationofBehaviouralPhenotypeinC57BL/6J FemaleMice NataliaKulesskaya,HeikkiRauvala,VooteleVoikar* DepartmentofBiosciencesandNeuroscienceCenter,UniversityofHelsinki,Helsinki,Finland Abstract Housing conditions represent an important environmental variable playing a critical role in the assessment of mouse behaviour.InthepresentstudytheeffectsofisolationandnestingmaterialonthebehaviouroffemaleC57BL/6Jmicewere evaluated.Themiceweresubjectedtodifferentrearingconditionsfromweaning(attheageof3weeks).Thestudygroups were group- and single-housed mice, divided further into groups with or without nesting material (species-specific enrichment).After8weeksspentinrespectiveconditionsthebehaviouraltestingbegan.Bothfactors(socialconditionsand nestingmaterial)appearedtohaveasignificantimpactonthebehaviouralphenotype.However,itisimportanttostress thattheinteractionbetweenthefactorswasvirtuallyabsent.Weestablishedthatisolationincreasedlocomotoractivityand reducedanxiety-likebehaviourinseveraltestsofexploration.Incontrast,absenceofnestingmaterialincreasedanxiety-like behaviour.Neitherfactoraffectedrota-rodperformance,nociceptionandprepulseinhibition.Contextualfearmemorywas significantlyreducedinsingle-housedmice,andinterestingly,inmicewithnestingmaterial.Cuedfearmemorywasreduced by single-housing, but not affected by enrichment. Mice from enriched cages displayed faster and better learning and spatial search strategy in the water maze. In contrast, isolation caused significant impairment in the water maze. In conclusion, both isolation and species-specific enrichment have profound effects on mouse behaviour and should be consideredindesignoftheexperimentsandinassessmentofanimalwelfareissues. Citation:KulesskayaN,RauvalaH,VoikarV(2011)EvaluationofSocialandPhysicalEnrichmentinModulationofBehaviouralPhenotypeinC57BL/6JFemale Mice.PLoSONE6(9):e24755.doi:10.1371/journal.pone.0024755 Editor:EfthimiosM.C.Skoulakis,AlexanderFlemmingBiomedicalScie