Estimation of the Burden of Pandemic(H1N1)2009 in Developing Countries Experience from a Tertiary Care Center in South India 英文参考文献.docVIP

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Estimation of the Burden of Pandemic(H1N1)2009 in Developing Countries Experience from a Tertiary Care Center in South India 英文参考文献.doc

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Estimation of the Burden of Pandemic(H1N1)2009 in Developing Countries Experience from a Tertiary Care Center in South India 英文参考文献

EstimationoftheBurdenofPandemic(H1N1)2009in DevelopingCountries:ExperiencefromaTertiaryCare CenterinSouthIndia MaheshMoorthy1,PrasannaSamuel2,JohnVictorPeter4,SaranyaVijayakumar1,DipikaSekhar1, ValsanP.Verghese3,IndiraAgarwal3,PrabhakarD.Moses3,KalaEbenezer3 ,Ooriapadickal CherianAbraham4,KurienThomas4,PrasadMathews4,AkhileshC.Mishra6,RenuLal7, JayaprakashMuliyil5,AshaMaryAbraham1* 1DepartmentofClinicalVirology,ChristianMedicalCollege,Vellore,TamilNadu,India,2DepartmentofBiostatistics,ChristianMedicalCollege,Vellore,TamilNadu,India, 3Department of Child Health, Christian Medical College, Vellore, Tamil Nadu, India, 4Department of Medicine, Christian Medical College, Vellore, Tamil Nadu, India, 5ChristianMedicalCollege,Vellore,TamilNadu,India,6NationalInstituteofVirology,Pune,Maharashtra,India,7InfluenzaDivision,NationalCenterforImmunization andResppiratoryDiseases,CentersforDiseaseControlandPrevention,Atlanta,Georgia,UnitedStatesofAmerica Abstract Background: The burden of the pandemic (H1N1) 2009 influenza might be underestimated if detection of the virus is mandated to diagnose infection. Using an alternate approach, we propose that a much higher pandemic burden was experiencedinourinstitution. Methodology/PrincipalFindings:Consecutivepatients(n=2588)presentingtoourhospitalwithinfluenzalikeillness(ILI) orsevereacuterespiratoryinfection(SARI)duringa1-yearperiod(May2009–April2010)wereprospectivelyrecruitedand testedforinfluenzaAbyreal-timeRT-PCR.Analysisofweeklytrendsshowedan11-foldincreaseinpatientspresentingwith ILI/SARI during the peak pandemic period when compared with the pre-pandemic period and a significant (P,0.001) increaseinSARIadmissionsduringthepandemicperiod(30615.9admissions/week)whencomparedwithpre-pandemic (762.5)andpost-pandemicperiods(563.8).However,InfluenzaAwasdetectedinlessthanone-thirdofpatientswithILI/ SARI [699 (27.0%)]; a majority of these (557/699, 79.7%) were Pandemic (H1N1)2009 virus [A/H1N1/09]. An A/H1N1/09 positivetestwascorrelatedwi