Evidence for D1 Dopamine Receptor Activation by a Paracrine Signal of Dopamine in Tick Salivary Glands 英文参考文献.docVIP

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Evidence for D1 Dopamine Receptor Activation by a Paracrine Signal of Dopamine in Tick Salivary Glands 英文参考文献.doc

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Evidence for D1 Dopamine Receptor Activation by a Paracrine Signal of Dopamine in Tick Salivary Glands 英文参考文献

EvidenceforD1DopamineReceptorActivationbya ParacrineSignalofDopamineinTickSalivaryGlands LadislavSimoˇ 1,JurajKocˇi1,Dusˇan Zitnˇ ˇan2,YoonseongPark1* 1Department of Entomology, Kansas State University, Manhattan, Kansas, United States of America, 2Institute of Zoology, Slovak Academy of Sciences, Bratislava, Slovakia Abstract Ticksthatfeedonvertebratehostsusetheirsalivarysecretion,whichcontainsvariousbioactivecomponents,tomanipulate thehost’sresponses.Themechanismscontrollingtheticksalivaryglandinthisdynamicprocessarenotwellunderstood. WeidentifiedthetickD1receptoractivatedbydopamine,apotentinducerofthesalivarysecretionofticks.Temporaland spatial expression patterns examined by immunohistochemistry and reverse transcription polymerase chain reaction suggestthatthedopamineproducedinthebasalcellsofsalivaryglandaciniissecretedintothelumenandactivatestheD1 receptorsontheluminalsurfaceofthecellsliningtheacini.Therefore,weproposeaparacrinefunctionofdopaminethatis mediated by the D1 receptor in the salivary gland at an early phase of feeding. The molecular and pharmacological characterizationoftheD1receptorinthisstudyprovidesthefoundationforunderstandingthefunctionsofdopaminein theblood-feedingofticks. Citation:Simoˇ L,Kociˇ J,Zitnanˇ D,ParkY(2011)EvidenceforD1DopamineReceptorActivationbyaParacrineSignalofDopamineinTickSalivaryGlands.PLoS ˇ ONE6(1):e16158.doi:10.1371/journal.pone.0016158 Editor:ImmoHansen,NewMexicoStateUniversity,UnitedStatesofAmerica ReceivedOctober5,2010;AcceptedDecember13,2010;PublishedJanuary31,2011 Copyright: ? 2011 Simoˇ et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited. Funding:Thispaperiscontributionno.11-168-JfromtheKansasAgriculturalExperimentStation.TheprojectdescribedwassupportedbyNationalInstitutesof Health(NIH)GrantNumbersR01AI090062-01and1R21AI08113