Exploring the Mycobacteriophage Metaproteome Phage Genomics as an Educational Platform 英文参考文献.docVIP

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Exploring the Mycobacteriophage Metaproteome Phage Genomics as an Educational Platform 英文参考文献.doc

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Exploring the Mycobacteriophage Metaproteome Phage Genomics as an Educational Platform 英文参考文献

ExploringtheMycobacteriophageMetaproteome: PhageGenomicsasanEducationalPlatform Graham F.Hatfull1,2*,Marisa L.Pedulla1,2¤a,Deborah Jacobs-Sera1,2,Pauline M.Cichon1,2,Amy Foley3, Michael E.Ford1,2¤b,Rebecca M. Gonda1,2,Jennifer M.Houtz1,2,Andrew J.Hryckowian1,2,Vanessa A.Kelchner1,2¤c , Swathi Namburi1,2,Kostandin V.Pajcini1,2¤d,Mark G.Popovich4,Donald T.Schleicher1,2,Brian Z.Simanek1,2¤e , Alexis L.Smith1,2,Gina M.Zdanowicz1,2¤f,Vanaja Kumar5,Craig L.Peebles1,2,William R.Jacobs Jr.6,7 Jeffrey G.Lawrence1,2,Roger W. Hendrix1,2 , 1 Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, 2 Pittsburgh Bacteriophage Institute, University of Pittsburgh,Pittsburgh,Pennsylvania,UnitedStatesofAmerica,3HamptonHighSchool,AllisonPark,Pennsylvania,UnitedStatesofAmerica,4LincolnHighSchool,Elwood City,Pennsylvania,UnitedStatesofAmerica,5TuberculosisResearchCenter,ICMR,Chetpet,Chennai,India,6DepartmentofMicrobiologyandImmunology,AlbertEinstein CollegeofMedicine,NewYork,NewYork,UnitedStatesofAmerica,7HowardHughesMedicalInstitute,AlbertEinsteinCollegeofMedicine,NewYork,NewYork,United StatesofAmerica Bacteriophagesarethemostabundantformsoflifeinthebiosphereandcarrygenomescharacterizedbyhighgenetic diversityandmosaicarchitectures.Thecompletesequencesof30mycobacteriophagegenomesshowthemcollectively toencode101tRNAs,threetmRNAs,and3,357proteinsbelongingto1,536‘‘phamilies’’ofrelatedsequences,anda statistical analysis predicts that these represent approximately 50% of the total number of phamilies in the mycobacteriophage population. These phamilies contain 2.19 proteins on average; more than half (774) of them containjustasingleproteinsequence.Onlysixphamilieshaverepresentativesinmorethanhalfofthe30genomes, and only three—encoding tape-measure proteins, lysins, and minor tail proteins—are present in all 30 phages, althoughthesephamiliesarethemselveshighlymodular,suchthatnosingleaminoacidsequenceelementispresent inal