Fatty Fish Intake Decreases Lipids Related to Inflammation and Insulin Signaling—A Lipidomics Approach 英文参考文献.docVIP

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Fatty Fish Intake Decreases Lipids Related to Inflammation and Insulin Signaling—A Lipidomics Approach 英文参考文献.doc

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Fatty Fish Intake Decreases Lipids Related to Inflammation and Insulin Signaling—A Lipidomics Approach 英文参考文献

FattyFishIntakeDecreasesLipidsRelatedto InflammationandInsulinSignaling—ALipidomics Approach MariaLankinen1,2,UrsulaSchwab2,3,ArjaErkkila¨4,TuulikkiSeppa¨nen-Laakso1,Marja-LeenaHannila5, HannaMussalo6,SeppoLehto3,MattiUusitupa2,HelenaGylling2,3,MatejOresˇicˇ1* 1VTTTechnicalResearchCentreofFinland,Espoo,Finland,2DepartmentofClinicalNutrition,SchoolofPublicHealthandClinicalNutrition,UniversityofKuopio,Kuopio, Finland,3DepartmentofInternalMedicine,KuopioUniversityHospital,Kuopio,Finland,4DepartmentofPublicHealth,SchoolofPublicHealthandClinicalNutrition, UniversityofKuopio,Kuopio,Finland,5InformationTechnologyCentre,UniversityofKuopio,Kuopio,Finland,6DepartmentofClinicalPhysiologyandNuclearMedicine, KuopioUniversityHospital,Kuopio,Finland Abstract Background: The evidence of the multiple beneficial health effects of fish consumption is strong, but physiological mechanismsbehindtheseeffectsarenotcompletelyknown.Littleinformationisavailableontheeffectsofconsumptionof differenttypeoffish.Theaimofthisstudywastoinvestigatehowfattyfishorleanfishinadietaffectserumlipidomic profilesinsubjectswithcoronaryheartdisease. MethodologyandPrincipalFindings:Apilotstudywasdesignedwhichincludedaltogether33subjectswithmyocardial infarctionorunstableischemicattackinan8-weekparallelcontrolledintervention.Thesubjectswererandomizedtoeither fattyfish(n=11), leanfish(n=12)orcontrol(n=10)groups.Subjectsinthefishgroupshad4fishmealsperweekand subjects in the control group consumed lean beef, pork and chicken. A fish meal was allowed once a week maximum. Lipidomics analyses were performed using ultra performance liquid chromatography coupled to electrospray ionization mass spectrometry and gas chromatography. Multiple bioactive lipid species, including ceramides, lysophosphatidylcho- linesanddiacylglycerols,decreasedsignificantlyinthefattyfishgroup,whereasintheleanfishgroupcholesterolestersand specificlong-chaintriacylglycerolsincreasedsignificantly(FalseDiscoveryRateq-value,0.05). Conclusions/Si