Fatty-Acid Binding Proteins Modulate Sleep and Enhance Long-Term Memory Consolidation in Drosophila 英文参考文献.docVIP

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Fatty-Acid Binding Proteins Modulate Sleep and Enhance Long-Term Memory Consolidation in Drosophila 英文参考文献.doc

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Fatty-Acid Binding Proteins Modulate Sleep and Enhance Long-Term Memory Consolidation in Drosophila 英文参考文献

Fatty-AcidBindingProteinsModulateSleepandEnhance Long-TermMemoryConsolidationinDrosophila JasonR.Gerstner1*¤,WilliamM.Vanderheyden2,PaulJ.Shaw2,CharlesF.Landry3,JerryC.P.Yin1,4,5* 1DepartmentofGenetics,UniversityofWisconsin-Madison,Madison,Wisconsin,UnitedStatesofAmerica,2AnatomyandNeurobiology,WashingtonUniversitySchoolof Medicine,St.Louis,Missouri,UnitedStatesofAmerica,3ScarabGenomics,LLC,Madison,Wisconsin,UnitedStatesofAmerica,4DepartmentofNeurology,Universityof Wisconsin-Madison,Madison,Wisconsin,UnitedStatesofAmerica,5WaismanCenter,UniversityofWisconsin-Madison,Madison,Wisconsin,UnitedStatesofAmerica Abstract Sleep is thought to be important for memory consolidation, since sleep deprivation has been shown to interfere with memoryprocessing.However,theeffectsofaugmentingsleeponmemoryformationarenotwellknown,andtestingthe roleofsleepinmemoryenhancementhasbeenlimitedtopharmacologicalandbehavioralapproaches.Herewetestthe effectofoverexpressingthebrain-typefattyacidbindingprotein(Fabp7)onsleepandlong-termmemory(LTM)formation inDrosophilamelanogaster.TransgenicfliescarryingthemurineFabp7ortheDrosophilahomologuedFabphadreduced baselinesleepbutnormalLTM,whileFabpinductionproducedincreasesinbothnetsleepandLTM.Wealsodefineapost- training consolidation ‘‘window’’ that is sufficient for the observed Fabp-mediated memory enhancement. Since Fabp overexpressionincreasesconsolidateddaytimesleepbouts,thesedatasupportaroleforlongernapsinimprovingmemory and provide a novel role for lipid-binding proteins in regulating memory consolidation concurrently with changes in behavioralstate. Citation: Gerstner JR, Vanderheyden WM, Shaw PJ, Landry CF, Yin JCP (2011) Fatty-Acid Binding Proteins Modulate Sleep and Enhance Long-Term Memory ConsolidationinDrosophila.PLoSONE6(1):e15890.doi:10.1371/journal.pone.0015890 Editor:WimCrusio,Universite′ deBordeauxandCentreNationaldelaRechercheScientifique,France ReceivedSeptember4,2010;AcceptedNovember25,2010;PublishedJanuary27,2011 Copyright: ? 201