Feedback Control Architecture and the Bacterial Chemotaxis Network 英文参考文献.docVIP

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Feedback Control Architecture and the Bacterial Chemotaxis Network 英文参考文献.doc

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Feedback Control Architecture and the Bacterial Chemotaxis Network 英文参考文献

FeedbackControlArchitectureandtheBacterial ChemotaxisNetwork AbdullahHamadeh1,2,MarkA.J.Roberts1,2,3,EliasAugust1,2,PatrickE.McSharry2,4,PhilipK.Maini2,5 , JudithP.Armitage2,3,AntonisPapachristodoulou1,2 * 1Department of Engineering Science, University of Oxford, Oxford, United Kingdom, 2Oxford Centre for Integrative Systems Biology, Department of Biochemistry, Oxford, United Kingdom, 3Department of Biochemistry, University of Oxford, Oxford, United Kingdom, 4Mathematical Institute, University of Oxford, Oxford, United Kingdom,5CentreforMathematicalBiology,MathematicalInstitute,UniversityofOxford,Oxford,UnitedKingdom Abstract Bacteriamovetowardsfavourableandawayfromtoxicenvironmentsbychangingtheirswimmingpattern.Thisresponseis regulated by the chemotaxis signalling pathway, which has an important feature: it uses feedback to ‘reset’ (adapt) the bacterialsensingability,whichallowsthebacteriatosensearangeofbackgroundenvironmentalchanges.Theroleofthis feedbackhasbeenstudiedextensivelyinthesimplechemotaxispathwayofEscherichiacoli.Howeverithasbeenrecently foundthatthemajorityofbacteriahavemultiplechemotaxishomologuesoftheE.coliproteins,resultinginmorecomplex pathways. In this paper we investigate the configuration and role of feedback in Rhodobacter sphaeroides, a bacterium containing multiple homologues of the chemotaxis proteins found in E. coli. Multiple proteins could produce different possible feedback configurations, each having different chemotactic performance qualities and levels of robustness to variationsanduncertaintiesinbiologicalparametersandtointracellularnoise.Wedevelopfourmodelscorrespondingto differentfeedbackconfigurations.Usingaseriesofcarefullydesignedexperimentswediscriminatebetweenthesemodels and invalidate three of them. When these models are examined in terms of robustness to noise and parametric uncertainties,wefindthatthenon-invalidatedmodelissuperiortotheothers.Moreover,ithasa‘cascadecontrol’feedback architecturewhichisusedextensivelyinengin