Fitness of Mycobacterium tuberculosis Strains of the W-Beijing and Non-W-Beijing Genotype 英文参考文献.docVIP

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Fitness of Mycobacterium tuberculosis Strains of the W-Beijing and Non-W-Beijing Genotype 英文参考文献.doc

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Fitness of Mycobacterium tuberculosis Strains of the W-Beijing and Non-W-Beijing Genotype 英文参考文献

FitnessofMycobacteriumtuberculosisStrainsofthe W-BeijingandNon-W-BeijingGenotype AndreavonGroll1*,AnandiMartin1,MatthiasStehr2,MahavirSingh2,Franc?oise Portaels1 ,Pedro EduardoAlmeidadaSilva3,JuanCarlosPalomino1 1MycobacteriologyUnit,InstituteofTropicalMedicine,Antwerp,Belgium,2DepartmentofGenomeAnalysis,HelmholtzCentreforInfectionResearch,Braunswcheig, Germany,3LaboratoryofMycobacteriology,UniversidadeFederaldoRioGrande,RioGrande,Brazil Abstract Background: Multidrug resistant tuberculosis (MDR-TB) is a major threat for global tuberculosis control. The W-Beijing Mycobacteriumtuberculosisgenotypehasbeenassociatedwithdrugresistance.Elucidationofthemechanismsunderlyingthis epidemiologicalfindingmayhaveanimportantroleinthecontrolofMDR-TB.Theaimofthisstudywastoevaluatethefitness ofdrug-susceptibleandMDRM.tuberculosisstrainsoftheW-BeijinggenotypecomparedwiththatofNon-W-Beijingstrains. Methodology/Principal Findings: Fitness of M. tuberculosis strains was determined by evaluating the difference in the growth curves obtained in the MGIT960 automated system and assessing the competitive growth capacity between W- Beijingandnon-W-Beijingstrains.TheW-BeijingMDRstrainshadasignificantlongerlagphasedurationcomparedtothe other strains but did not present a significant fitness cost. When grown in competition they had an advantage only in mediumcontaining0.1%Tween80. Conclusions/Significance: It was not possible to confirm a selective advantage of W-Beijing strains to grow, except for differencesintheirresistance toTween80.Further studiesareneededtoelucidatetheputativeadvantageofW-Beijing strainscomparedtoothergenotypes. Citation: von Groll A, Martin A, Stehr M, Singh M, Portaels F, et al. (2010) Fitness of Mycobacterium tuberculosis Strains of the W-Beijing and Non-W-Beijing Genotype.PLoSONE5(4):e10191.doi:10.1371/journal.pone.0010191 Editor:DavidM.Ojcius,UniversityofCaliforniaMerced,UnitedStatesofAmerica ReceivedJanuary21,2010;AcceptedMarch8,2010;PublishedApril16,2010 C