Five Year Incidence of Visual Field Loss in Adult Chinese. The Beijing Eye Study. 英文参考文献.docVIP

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Five Year Incidence of Visual Field Loss in Adult Chinese. The Beijing Eye Study. 英文参考文献.doc

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Five Year Incidence of Visual Field Loss in Adult Chinese. The Beijing Eye Study. 英文参考文献

FiveYearIncidenceofVisualFieldLossinAdultChinese. TheBeijingEyeStudy. YaXingWang1,LiangXu1*,XiuYingSun1,YangZou1,HaiTaoZhang1,JostB.Jonas1,2* 1BeijingInstituteofOphthalmology,BeijingTongrenHospital,CapitalMedicalUniversity,Beijing,China,2DepartmentofOphthalmology,MedicalFacultyMannheimof theRuprecht-Karls-UniversityHeidelberg,Germany Abstract Purpose:Todescribethecumulative5yearincidenceofvisualfieldlossinadultChineseinGreaterBeijing. Methods: The Beijing Eye Study 2006 included 3251 subjects (mean age 60.4610.1years) who had participated in the Beijing Eye Study 2001 and returned for re-examination. All participants underwent a comprehensive eye examination, including visual field test by frequency doubling threshold perimetry. An abnormal visual field was defined as reduced sensitivity in at least one test location. Incident visual field loss was defined as a change in visual field from normal at baselinetoabnormalatfollow-up. Results: An incident visual field loss was detected in 273 eyes (4.360.5%) /235 subjects (7.360.5%). It was significantly associated with higher age (P=0.001), higher intraocular pressure (P,0.001), and higher fasting blood glucose concentration (P=0.019). Considering only eyes (n=140) with a detected cause for visual field loss, the most frequent causeswerecataract(68(48.6%)eyes)followedbyglaucoma(23(16.4%)eyes),diabeticretinopathy(13(9.3%)eyes),age- relatedmaculardegeneration(10(7.1%)eyes),andmyopicdegenerativeretinopathy(9(6.4%)eyes).For133(48.7%)eyes withavisualfieldloss,thecausefortheVFLremainedunclear. Conclusions: The 5-year incidence of visual field loss was 4.360.5% per eye or 7.360.5% per subject. It increased significantlywithage,intraocularpressure,andfastingbloodglucoselevel.Majorcausesfortheincidenceofvisualfieldloss werecataract,glaucomaanddiabeticretinopathy. Citation:WangYX,XuL,SunXY,ZouY,ZhangHT,etal.(2012)FiveYearIncidenceofVisualFieldLossinAdultChinese.TheBeijingEyeStudy.PLoSONE7(5): e37232.doi:10.1371/journal.pone.00