Five-Year Longitudinal Assessment of the Downstream Impact on Schistosomiasis Transmission following Closure of the Three Gorges Dam 英文参考文献.docVIP

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Five-Year Longitudinal Assessment of the Downstream Impact on Schistosomiasis Transmission following Closure of the Three Gorges Dam 英文参考文献.doc

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Five-Year Longitudinal Assessment of the Downstream Impact on Schistosomiasis Transmission following Closure of the Three Gorges Dam 英文参考文献

Five-YearLongitudinalAssessmentoftheDownstream ImpactonSchistosomiasisTransmissionfollowing ClosureoftheThreeGorgesDam DarrenJ.Gray1,2,3,AaronP.Thrift3,4,GailM.Williams3,FengZheng5,Yue-ShengLi1,6,JiagangGuo5, HonggenChen7,TianpingWang8,XinJiangXu9,RongZhu5,HongqingZhu5,ChunLiCao5,DanDanLin7, ZhenYuanZhao6,RobertS.Li2,3,GeorgeM.Davis10,DonaldP.McManus2* 1Molecular Parasitology Laboratory, InfectiousDiseases Division, Queensland Institute ofMedical Research, Herston, Brisbane, Queensland, Australia, 2Griffith Health Institute, Griffith University, Meadowbrook, Queensland, Australia, 3School of Population Health, University of Queensland, Brisbane, Queensland, Australia, 4Cancer ControlGroup,QueenslandInstituteofMedicalResearch,Brisbane,Queensland,Australia,5NationalInstituteofParasiticDisease,ChineseCentreforDiseaseControland Prevention,Shanghai,People’sRepublicofChina,6HunanInstituteofParasiticDiseases,WorldHealthOrganizationCollaboratingCentreforResearchandControlon SchistosomiasisinLakeRegion,Yueyang,People’sRepublicofChina,7JiangxiProvincialInstituteofParasiticDiseases,Nanchang,People’sRepublicofChina,8Anhui InstituteforSchistosomiasisControl,Hefei,People’sRepublicofChina,9HubeiInstituteforSchistosomiasisControl,Wuhan,People’sRepublicofChina,10Departmentof MicrobiologyandTropicalMedicine,GeorgeWashingtonUniversityMedicalCentre,WashingtonD.C.,UnitedStatesofAmerica Abstract Background:SchistosomajaponicumisamajorpublichealthconcerninthePeoples’RepublicofChina(PRC),withabout 800,000 people infected and another 50 million living in areas at risk of infection. Based on ecological, environmental, population genetic and molecular factors, schistosomiasis transmission in PRC can be categorised into four discrete ecosystems or transmission modes. It is predicted that, long-term, the Three Gorges Dam (TGD) will impact upon the transmissionofschistosomiasisinthePRC,withvaryingdegreeacrossthefourtransmissionmodes. Methodology/Principal Findings: We undertook longitudinal surv