Functional Anatomy of the Masking Level Difference, an fMRI Study 英文参考文献.docVIP

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Functional Anatomy of the Masking Level Difference, an fMRI Study 英文参考文献.doc

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Functional Anatomy of the Masking Level Difference, an fMRI Study 英文参考文献

FunctionalAnatomyoftheMaskingLevelDifference,an fMRIStudy DavidS.Wack1,2,4*,JenniferL.Cox1,ClaudiuV.Schirda1,3,ChristopherR.Magnano1,JoanE.Sussman4, DonaldHenderson4,RobertF.Burkard5 1BuffaloNeuroimagingAnalysisCenter,Dept.ofNeurology,UniversityatBuffalo,StateUniversityofNewYorkatBuffalo,Buffalo,NewYork,UnitedStatesofAmerica, 2Department of Nuclear Medicine, University atBuffalo, State University ofNew York at Buffalo, Buffalo, New York, United States of America, 3MR Research Center, DepartmentofRadiology,UniversityofPittsburgh,Pittsburgh,Pennsylvania,UnitedStatesofAmerica,4DepartmentofCommunicativeDisordersandSciences,University at Buffalo, State University of New York at Buffalo, Buffalo, New York, United States of America, 5Department of Rehabilitation Science, University at Buffalo, State UniversityofNewYorkatBuffalo,Buffalo,NewYork,UnitedStatesofAmerica Abstract Introduction: Masking level differences (MLDs) are differences in the hearing threshold for the detection of a signal presentedinanoisebackground,whereeitherthephaseofthesignalornoiseisreversedbetweenears.WeuseN0/Npto denotenoisepresentedin-phase/out-of-phasebetweenearsandS0/Sptodenotea500Hzsinewavesignalasin/out-of- phase.Signaldetectionlevelforthenoise/signalcombinationsN0SpandNpS0istypically10–20dBbetterthanforN0S0.All combinationshavethesamespectrum,level,anddurationofboththesignalandthenoise. Methods:Tenparticipants(5female),age:22–43,withN0Sp-N0S0MLDsgreaterthan10dB,wereimagedusingasparse BOLD fMRI sequence, with a 9 second gap (1 second quiet preceding stimuli). Band-pass (400–600Hz) noise and an enveloped signal (.25 second tone burst, 50% duty-cycle) were used to create the stimuli. Brain maps of statistically significantregionswereformedfromasecond-levelanalysisusingSPM5. Results: The contrast NpS0- N0Sp had significant regions of activation in the right pulvinar, corpus callosum, and insula bilaterally. The leftinferior frontal gyrus had significant activation for contrasts N0Sp-N0S0 and Np