Functional Roles for Synaptic-Depression within a Model of the Fly Antennal Lobe 英文参考文献.docVIP

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Functional Roles for Synaptic-Depression within a Model of the Fly Antennal Lobe 英文参考文献.doc

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Functional Roles for Synaptic-Depression within a Model of the Fly Antennal Lobe 英文参考文献

FunctionalRolesforSynaptic-DepressionwithinaModel oftheFlyAntennalLobe AadityaV.Rangan* CourantInstituteofMathematicalSciences,NewYorkUniversity,NewYork,NewYork,UnitedStatesofAmerica Abstract Severalexperimentsindicatethatthereexistssubstantialsynaptic-depressionatthesynapsesbetweenolfactoryreceptor neurons(ORNs)andneuronswithinthedrosophilaantennalobe(AL).Thissynaptic-depressionmaybepartlycausedby vesicle-depletion,andpartlycausedbypresynaptic-inhibitionduetotheactivityofinhibitorylocalneuronswithintheAL. While it has been proposed that this synaptic-depression contributes to the nonlinear relationship between ORN and projectionneuron(PN)firing-rates,theprecisefunctionalroleofsynaptic-depressionattheORNsynapsesisnotyetfully understood. In this paper we propose two hypotheses linking the information-coding properties of the fly AL with the network mechanisms responsible for ORN?AL synaptic-depression. Our first hypothesis is related to variance coding of ORNfiring-rateinformation—oncestimulationtotheORNsissufficientlyhightosaturateglomerularresponses,further stimulation of the ORNs increases the regularity of PN spiking activity while maintaining PN firing-rates. The second hypothesisproposesatradeoffbetweenspike-timereliabilityandcoding-capacitygovernedbytherelativecontributionof vesicle-depletion and presynaptic-inhibition to ORN?AL synaptic-depression. Synaptic-depression caused primarily by vesicle-depletion will give rise to a very reliable system, whereas an equivalent amount of synaptic-depression caused primarily by presynaptic-inhibition will give rise to a less reliable system that is more sensitive to small shifts in odor stimulation.ThesetwohypothesesaresubstantiatedbyseveralsmallanalyzabletoymodelsoftheflyAL,aswellasamore physiologicallyrealisticlarge-scalecomputationalmodeloftheflyALinvolving5glomerularchannels. Citation:RanganAV(2012)FunctionalRolesforSynaptic-DepressionwithinaModeloftheFlyAntennalLobe.PLoSComputBiol8(8):e1002622.doi:10.1371/ journa