G-Cimp Status Prediction Of Glioblastoma Samples Using mRNA Expression Data 英文参考文献.docVIP

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G-Cimp Status Prediction Of Glioblastoma Samples Using mRNA Expression Data 英文参考文献.doc

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G-Cimp Status Prediction Of Glioblastoma Samples Using mRNA Expression Data 英文参考文献

G-CimpStatusPredictionOfGlioblastomaSamplesUsing mRNAExpressionData MehmetBaysan1,SerdarBozdag2,MargaretC.Cam1,SvetlanaKotliarova1,SusieAhn1, JenniferWalling1,JonathanK.Killian3,HollyStevenson3,PaulMeltzer3,HowardA.Fine1,4* 1Neuro-OncologyBranch,NationalCancerInstitute,NationalInstitutesofHealth,Bethesda,Maryland,UnitedStatesofAmerica,2DepartmentofMathematics,Statistics, andComputerScience,MarquetteUniversity,Milwaukee,Wisconsin,UnitedStatesofAmerica,3GeneticsBranch,NationalCancerInstitute,NationalInstitutesofHealth, Bethesda,Maryland,UnitedStatesofAmerica,4NewYorkUniversityCancerInstitute,NewYorkUniversityLangoneMedicalCenter,NewYork,NewYork,UnitedStatesof America Abstract Glioblastoma Multiforme (GBM) is a tumor with high mortality and no known cure. The dramatic molecular and clinical heterogeneity seen in this tumor has led to attempts to define genetically similar subgroups of GBM with the hope of developingtumorspecifictherapiestargetedtotheuniquebiologywithineachofthesesubgroups.Recently,asubsetof relativelyfavorableprognosisGBMshasbeenidentified.ThesegliomaCpGislandmethylatorphenotype,orG-CIMPtumors, havedistinctgenomiccopynumberaberrations,DNAmethylationpatterns,and(mRNA)expressionprofilescomparedto otherGBMs.WhilethestandardmethodforidentifyingG-CIMPtumorsisbasedongenome-wideDNAmethylationdata, such data is often not available compared to the more widely available gene expression data. In this study, we have developedandevaluatedamethodtopredicttheG-CIMPstatusofGBMsamplesbasedsolelyongeneexpressiondata. Citation:BaysanM,BozdagS,CamMC,KotliarovaS,AhnS,etal.(2012)G-CimpStatusPredictionOfGlioblastomaSamplesUsingmRNAExpressionData.PLoS ONE7(11):e47839.doi:10.1371/journal.pone.0047839 Editor:MariaG.Castro,UniversityofMichiganSchoolofMedicine,UnitedStatesofAmerica ReceivedJuly31,2012;AcceptedSeptember21,2012;PublishedNovember6,2012 Thisisanopen-accessarticle,freeofallcopyright,andmaybefreelyreproduced,distributed,transmitted,modified,builtupon,orotherwiseusedb