Genetic Variants of Diabetes Risk and Incident Cardiovascular Events in Chronic Coronary Artery Disease 英文参考文献.docVIP

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Genetic Variants of Diabetes Risk and Incident Cardiovascular Events in Chronic Coronary Artery Disease 英文参考文献.doc

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Genetic Variants of Diabetes Risk and Incident Cardiovascular Events in Chronic Coronary Artery Disease 英文参考文献

GeneticVariantsofDiabetesRiskandIncident CardiovascularEventsinChronicCoronaryArtery Disease Andre′ GustavoP.Sousa1,2*,NeuzaH.Lopes3,WhadyA.Hueb3,Jose′ EduardoKrieger1,AlexandreC. Pereira1 1Laboratory ofGeneticsandMolecularCardiology,MedicalSchool,HeartInstitute,UniversityofSa?o Paulo,Sa?o Paulo,Brazil, 2ClinicalMedicineDepartment,Federal UniversityofRioGrandedoNorte,Natal,Brazil,3CoronaryArteryDiseaseService,MedicalSchool,HeartInstitute,UniversityofSa?o Paulo,Sa?o Paulo,Brazil Abstract Objective: To determine whether information from genetic risk variants for diabetes is associated with cardiovascular eventsincidence. Methods:Fromtheabout30knowngenesassociatedwithdiabetes,wegenotypedsingle-nucleotidepolymorphismsat the10locimostassociatedwithtype-2diabetesin425subjectsfromtheMASS-IIStudy,arandomizedstudyinpatients withmulti-vesselcoronaryarterydisease.Thecombinedgeneticinformationwasevaluatedbynumberofriskallelesfor diabetes.PerformanceofgeneticmodelsrelativetomajorcardiovasculareventsincidencewasanalyzedthroughKaplan- MeiercurvecomparisonandCoxHazardModelsandthediscriminatoryabilityofmodelswasassessedforcardiovascular eventsbycalculatingtheareaundertheROCcurve. Results:Geneticinformationwasabletopredict5-yearincidenceofmajorcardiovasculareventsandoverall-mortalityin non-diabetic individuals, even after adjustment for potential confounders including fasting glycemia. Non-diabetic individuals with high genetic risk had a similar incidence of events then diabetic individuals (cumulative hazard of 33.0 versus 35.1% of diabetic subjects). The addition of combined genetic information to clinical predictors significantly improvedtheAUCforcardiovasculareventsincidence(AUC=0.641versus0.610). Conclusions: Combined information of genetic variants for diabetes risk is associated to major cardiovascular events incidence,includingoverallmortality,innon-diabeticindividualswithcoronaryarterydisease. Clinical Trial Registration Information: Medicine, Angio