Genome-Scale Screen for DNA Methylation-Based Detection Markers for Ovarian Cancer 英文参考文献.docVIP
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Genome-Scale Screen for DNA Methylation-Based Detection Markers for Ovarian Cancer 英文参考文献
Genome-ScaleScreenforDNAMethylation-Based
DetectionMarkersforOvarianCancer
MihaelaCampan1.,MelissaMoffitt2.,SaharHoushdaran3,HuiShen8,MartinWidschwendter4,Gu¨nter
Daxenbichler5,TiffanyLong1,ChristianMarth5,IteA.Laird-Offringa1,3,MichaelF.Press9,LouisDubeau9,
KimberlyD.Siegmund7,AnnaH.Wu7,SusanGroshen7,UmaChandavarkar2,LyndaD.Roman2 ,Andrew
Berchuck6,CelesteL.Pearce7,PeterW.Laird1,3,8*
1DepartmentofSurgery,KeckSchoolofMedicine,UniversityofSouthernCalifornia,LosAngeles,California,UnitedStatesofAmerica,2DepartmentofObstetricsand
GynecologyDivisionofGynecologicOncology,KeckSchoolofMedicine,UniversityofSouthernCalifornia,LosAngeles,California,UnitedStatesofAmerica,3Department
ofBiochemistry andMolecularBiology, KeckSchoolofMedicine,UniversityofSouthernCalifornia,LosAngeles,California,UnitedStatesofAmerica,4Department of
GynecologicalOncology,ElizabethGarrettAndersonInstituteforWomen’sHealth,UniversityCollegeLondon,London,UnitedKingdom,5DepartmentofObstetricsand
Gynecology,Innsbruck MedicalUniversity,Innsbruck,Austria,6DepartmentofObstetricsandGynecologyDivisionofGynecologicOncology,DukeUniversityMedical
Center,Durham,NorthCarolina,UnitedStatesofAmerica,7DepartmentofPreventiveMedicine,KeckSchoolofMedicine,UniversityofSouthernCalifornia,LosAngeles,
California,UnitedStatesofAmerica,8UniversityofSouthernCaliforniaEpigenomeCenter,UniversityofSouthernCalifornia,LosAngeles,CA,UnitedStatesofAmerica,
9DepartmentofPathology,KeckSchoolofMedicine,UniversityofSouthernCalifornia,LosAngeles,California,UnitedStatesofAmerica
Abstract
Background:Theidentificationofsensitivebiomarkersforthedetectionofovariancancerisofhighclinicalrelevancefor
earlydetectionand/ormonitoringofdiseaserecurrence.Wedevelopedasystematicmulti-stepbiomarkerdiscoveryand
verificationstrategytoidentifycandidateDNAmethylationmarkersfortheblood-baseddetectionofovariancancer.
Methodology/PrincipalFindings:WeusedtheIlluminaInfiniumplatformtoanalyzetheDNAmethylationstatusof27,578
CpG sites in 41 ovarian tumors.
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