Genome-Wide Population-Based Association Study of Extremely Overweight Young Adults – The GOYA Study 英文参考文献.docVIP

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2017-05-11 发布于上海
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Genome-Wide Population-Based Association Study of Extremely Overweight Young Adults – The GOYA Study 英文参考文献.doc

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Genome-Wide Population-Based Association Study of Extremely Overweight Young Adults – The GOYA Study 英文参考文献

Genome-WidePopulation-BasedAssociationStudyof ExtremelyOverweightYoungAdults–TheGOYAStudy LaviniaPaternoster1,2*,DavidM.Evans1,2,EllenAagaardNohr3,ClausHolst4,ValerieGaborieau5 ,Paul Brennan5,AnettePriorGjesing6,NielsGrarup6,DanielR.Witte8,TorbenJ?rgensen9,10,AllanLinneberg9, TorstenLauritzen11,AnelliSandbaek11,TorbenHansen6,7,OlufPedersen6,12,13,KatherineS.Elliott14, JohnP.Kemp1,2,BeateSt.Pourcain2,GeorgeMcMahon1,2,DianaZelenika15,Jo¨rgHager15 ,Mark Lathrop15,16,NicholasJ.Timpson1,2,GeorgeDaveySmith1,2,ThorkildI.A.S?rensen4 1MRCCAiTEcentre,UniversityofBristol,Bristol,UnitedKingdom,2SchoolofSocialandCommunityMedicine,UniversityofBristol,Bristol,UnitedKingdom,3Instituteof PublicHealth,AarhusUniversity,Aarhus,Denmark,4InstituteofPreventiveMedicine,CopenhagenUniversityHospitals,Copenhagen,Denmark,5InternationalAgency for Research on Cancer (IARC), Lyon, France, 6The Novo Nordisk Center for Metabolic Research, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark, 7Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark, 8Steno Diabetes Center, Copenhagen, Denmark, 9Research Centre for PreventionandHealth,GlostrupUniversityHospital,Glostrup,Denmark,10FacultyofHealthScience,UniversityofCopenhagen,Copenhagen,Denmark,11Department ofGeneralPractice,UniversityofAarhus,Aarhus,Denmark,12InstituteofBiomedicalScience,FacultyofHealthScience,UniversityofCopenhagen,Copenhagen,Demark, 13Faculty of Health Science, University of Aarhus, Aarhus,Denmark, 14Wellcome Trust Centre for Human Genetics, Oxford, United Kingdom, 15Centre National de Ge′notypage, Evry,France,16FoundationJeanDausset,CEPH,Paris,France Abstract Background: Thirty-two common variants associated with body mass index (BMI) have been identified in genome-wide association studies, explaining ,1.45% of BMI variation in general population cohorts. We performed a genome-wide associationstudyinasampleofyoungadultsenrichedforextremelyoverweightindividuals.Weaimedtoidentifynewloci assoc