Hippocampal CA3 Transcriptome Signature Correlates with Initial Precipitating Injury in Refractory Mesial Temporal Lobe Epilepsy 英文参考文献.docVIP

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Hippocampal CA3 Transcriptome Signature Correlates with Initial Precipitating Injury in Refractory Mesial Temporal Lobe Epilepsy 英文参考文献.doc

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Hippocampal CA3 Transcriptome Signature Correlates with Initial Precipitating Injury in Refractory Mesial Temporal Lobe Epilepsy 英文参考文献

HippocampalCA3TranscriptomeSignatureCorrelates withInitialPrecipitatingInjuryinRefractoryMesial TemporalLobeEpilepsy SilviaY.Bando1,MaryanaC.Alegro2,EdsonAmaro Jr3,AlexandreV.Silva4,LuizH.M.Castro5 ,Hung- TzuWen6,LeandrodeA.Lima7,HelenaBrentani8,CarlosAlbertoMoreira-Filho1* 1Department of Pediatrics, Faculdade de Medicina da Universidade de Sa?o Paulo (FMUSP), Sa?o Paulo, Sa?o Paulo, Brazil, 2Laboratory of Integrated Systems, Escola Polite′cnicadaUniversidadedeSa?o Paulo,Sa?o Paulo,Sa?o Paulo,Brazil,3DepartmentofRadiology,FaculdadedeMedicinadaUniversidadedeSa?o Paulo(FMUSP),Sa?o Paulo,Sa?o Paulo,Brazil,4DepartmentofBiosciences,UniversidadeFederaldeSa?o Paulo,Santos,Sa?o Paulo,Brazil,5ClinicalNeurologyDivision,HospitaldasCl?′nicasda Faculdade de Medicina da Universidade de Sa?o Paulo, Sa?o Paulo, Sa?o Paulo, Brazil, 6Epilepsy Surgery Group, Hospital das Cl?′nicas da Faculdade de Medicina da UniversidadedeSa?o Paulo,Sa?o Paulo,Sa?o Paulo,Brazil,7LaboratoryofBiotechnology,HospitaldoCa?ncer ACCamargo,Sa?o Paulo,Sa?o Paulo,Brazil,8Departmentof Psychiatry, Instituto Nacional de Psiquiatria do Desenvolvimento and Laborato′rio de Investigac?a?o Me′dica 23, Faculdade de Medicina da Universidade de Sa?o Paulo (FMUSP),Sa?o Paulo,Sa?o Paulo,Brazil Abstract Background:Prolongedfebrileseizuresconstituteaninitialprecipitatinginjury(IPI)commonlyassociatedwithrefractory mesial temporallobeepilepsy(RMTLE). Inorder toinvestigate IPIinfluence onthetranscriptional phenotypeunderlying RMTLEwecomparativelyanalyzedthetranscriptomicsignaturesofCA3explantssurgicallyobtainedfromRMTLEpatients with(FS) orwithout (NFS)febrileseizure history.Texture analyseson MRIimages ofdentate gyruswere conductedina subsetofsurgicallyremovedsclerotichippocampiforidentifyingIPI-associatedhisto-radiologicalalterations. Methodology/PrincipalFindings:DNAmicroarrayanalysisrevealedthatCA3globalgeneexpressiondifferedsignificantly betweenFSandNFSsubgroups.Anintegrativefunctionalgenomicsmeth