Hippocampal Deletion of BDNF Gene Attenuates Gamma Oscillations in Area CA1 by Up-Regulating 5-HT3 Receptor 英文参考文献.docVIP

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Hippocampal Deletion of BDNF Gene Attenuates Gamma Oscillations in Area CA1 by Up-Regulating 5-HT3 Receptor 英文参考文献.doc

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Hippocampal Deletion of BDNF Gene Attenuates Gamma Oscillations in Area CA1 by Up-Regulating 5-HT3 Receptor 英文参考文献

HippocampalDeletionofBDNFGeneAttenuatesGamma OscillationsinAreaCA1byUp-Regulating5-HT3 Receptor YingHuang1,2,AlexeiMorozov1* 1UnitonBehavioralGenetics,LaboratoryofMolecularPathophysiology,NationalInstitute ofMentalHealth,NationalInstitutesofHealth,Bethesda,Maryland,United StatesofAmerica,2DepartmentofPhysiologyandPathophysiology,ShanghaiMedicalCollege,FudanUniversity,Shanghai,China Abstract Background:PyramidalneuronsinthehippocampalareaCA3expresshighlevelsofBDNF,buthowthisBDNFcontributes tooscillatorypropertiesofhippocampusisunknown. Methodology/PrincipalFindings:Hereweexaminedcarbachol-inducedgammaoscillationsinhippocampalsliceslacking BDNF genein thearea CA3. Thepower ofoscillations was reducedin thehippocampal area CA1,which coincided with increasesintheexpressionandactivityof5-HT3receptor.Pharmacologicalblockofthisreceptorpartiallyrestoredpowerof gammaoscillationsinslicesfromKOmice,buthadnoeffectinslicesfromWTmice. Conclusion/Significance:ThesedatasuggestthatBDNFfacilitatesgammaoscillationsinthehippocampusbyattenuating signalingthrough5-HT3receptor.Thus,BDNFmodulateshippocampaloscillationsthroughserotonergicsystem. Citation:HuangY,MorozovA(2011)HippocampalDeletionofBDNFGeneAttenuatesGammaOscillationsinAreaCA1byUp-Regulating5-HT3Receptor.PLoS ONE6(1):e16480.doi:10.1371/journal.pone.0016480 Editor:KenjiHashimoto,ChibaUniversityCenterforForensicMentalHealth,Japan ReceivedAugust27,2010;AcceptedDecember21,2010;PublishedJanuary26,2011 Thisisanopen-accessarticledistributedunderthetermsoftheCreativeCommonsPublicDomaindeclarationwhichstipulatesthat,onceplacedinthepublic domain,thisworkmaybefreelyreproduced,distributed,transmitted,modified,builtupon,orotherwiseusedbyanyoneforanylawfulpurpose. Funding:TheworkwassupportedbytheNationalInstitutesofHealthNationalInstituteofMentalHealthIntramuralResearchProgram.Thefundershadnorole instudydesign,datacollectionandanalysis,decisiontopublish,orpreparationofthemanuscript. CompetingInterests:Theauthorshavedeclaredthatnocompetin