Maternal Geohelminth Infections Are Associated with an Increased Susceptibility to Geohelminth Infection in Children A Case-Control Study 英文参考文献.docVIP

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Maternal Geohelminth Infections Are Associated with an Increased Susceptibility to Geohelminth Infection in Children A Case-Control Study 英文参考文献.doc

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Maternal Geohelminth Infections Are Associated with an Increased Susceptibility to Geohelminth Infection in Children A Case-Control Study 英文参考文献

MaternalGeohelminthInfectionsAreAssociatedwithan IncreasedSusceptibilitytoGeohelminthInfectionin Children:ACase-ControlStudy RaajS.Mehta1,AlejandroRodriguez1,MarthaChico1,2,IreneGuadalupe1,2,NelyBroncano1,2 , CarlosSandoval1,2,FernandaTupiza1,3,EdwardMitre4,PhilipJ.Cooper1,2,3,5* 1Laboratorio de Investigaciones, Fundacion Ecuatoriana Para la Investigacion en Salud (FEPIS), Quininde′, Esmeraldas Province, Ecuador, 2Hospital ‘‘Padre Alberto Buffoni,’’Quininde′, EsmeraldasProvince,Ecuador,3ColegiodeCienciasdelaSalud,UniversidadSanFranciscodeQuito,Quito,Ecuador,4UniformedServicesUniversity oftheHealthSciences,Bethesda,Maryland,UnitedStatesofAmerica,5MolecularandBiochemicalParasitology,LiverpoolSchoolofTropicalMedicine,Liverpool,United Kingdom Abstract Background: Childrenofmothers infectedwithsoil-transmitted helminths (STH)mayhaveanincreased susceptibility to STHinfection. MethodsandFindings:Wedidacase-controlstudynestedinabirthcohortinEcuador.Datafrom1,004childrenaged7 monthsto3yearswereanalyzed.CasesweredefinedaschildrenwithAscarislumbricoidesand/orTrichuristrichiura ,controls without. Exposure was defined as maternal infection with A. lumbricoides and/or T. trichiura, detected during the third trimesterofpregnancy.Theanalysiswasrestrictedtohouseholdswithadocumentedinfectiontocontrolforinfectionrisk. Children of mothers with STH infections had a greater risk of infection compared to children of uninfected mothers (adjusted OR2.61, 95%CI: 1.88–3.63, p,0.001). Thiseffect was particularly strong in children ofmothers with both STH infections(adjustedOR:5.91,95%CI:3.55–9.81,p,0.001).NewbornsofinfectedmothershadgreaterlevelsofplasmaIL-10 thanthoseofuninfectedmothers(p=0.033),andtherewasevidencethatcordbloodIL-10wasincreasedamongnewborns whobecameinfectedlaterinchildhood(p=0.060). Conclusion:OurdatasuggestthatmaternalSTHinfectionsincreasesusceptibilitytoinfectionduringearlychildhood,an effectthatwasassociatedwithelevatedIL-10incordplasma. Citation:MehtaRS,RodriguezA,C