Maternal Infection with Trypanosoma cruzi and Congenital Chagas Disease Induce a Trend to a Type 1 Polarization of Infant Immune Responses to Vaccines 英文参考文献.docVIP

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Maternal Infection with Trypanosoma cruzi and Congenital Chagas Disease Induce a Trend to a Type 1 Polarization of Infant Immune Responses to Vaccines 英文参考文献.doc

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Maternal Infection with Trypanosoma cruzi and Congenital Chagas Disease Induce a Trend to a Type 1 Polarization of Infant Immune Responses to Vaccines 英文参考文献

MaternalInfectionwithTrypanosomacruziand CongenitalChagasDiseaseInduceaTrendtoaType1 PolarizationofInfantImmuneResponsestoVaccines NicolasDauby1,CristinaAlonso-Vega2,EduardoSuarez2,AmilcarFlores2,EmmanuelHermann1 ,Marisol Co′rdova2,TatianaTellez2,FaustinoTorrico2,CarineTruyens1*,YvesCarlier1 1Laboratoire de Parasitologie, Faculte′ de Me′decine, Universite′ Libre de Bruxelles (ULB), Brussels, Belgium, 2Facultad de Medicina, Universidad Mayor de San Simon (UMSS),Cochabamba,Bolivia Abstract Background:WepreviouslyshowedthatnewbornscongenitallyinfectedwithTrypanosomacruzi(M+B+)displayastrong type1parasite-specificTcellimmuneresponse,whereasuninfectednewbornsfromT.cruzi-infectedmothers(M+B2 )are pronetoproducehigherlevelsofproinflammatorycytokinesthancontrolneonates(M2B2).Thepurposeofthepresent studywastodetermineifsuchfetal/neonatalimmunologicalenvironmentscouldaltertheresponsetostandardvaccines administeredinearlylife. Methodology:Infants(6–7monthsold)livinginBolivia,anareahighlyendemicforT.cruziinfection,andhavingreceived Bacillus Calmette Guerin (BCG), hepatitis B virus (HBV), diphtheria and tetanus vaccines, were enrolled into the M+B+, M+B2, M2B2 groups mentioned above. The production of IFN-c and IL-13, as markers of Th1 and Th2 responses respectively, by peripherical blood mononuclear cells stimulated with tuberculin purified protein derivative of Mycobacterium tuberculosis (PPD) or the vaccinal antigens HBs, diphtheria toxoid (DT) or tetanus toxoid (TT), as well as circulating levels of IgG antibodies against HBsAg, DT and TT were analyzed in infants. Cellular responses to the superantigenSEBwerealsomonitoredinM+B+,M+B2,M2B2infantsandnewborns. PrincipalFindings:M+B+infantsdevelopedastrongerIFN-cresponsetohepatitisB,diphtheriaandtetanusvaccinesthan didM+B2andM2B2groups.TheyalsodisplayedanenhancedantibodyproductiontoHBsAg.Thiswasassociatedwitha type1-biasedimmuneenvironmentatbirth,sincecellsofM+B+newbornsproducedhigherIFN-clevelsinresponsetoSEB. M+B2infantspro