Molecular Epidemiology of Influenza A(H1N1)pdm09 Viruses from Pakistan in 2009–2010 英文参考文献.docVIP

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Molecular Epidemiology of Influenza A(H1N1)pdm09 Viruses from Pakistan in 2009–2010 英文参考文献.doc

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Molecular Epidemiology of Influenza A(H1N1)pdm09 Viruses from Pakistan in 2009–2010 英文参考文献

MolecularEpidemiologyofInfluenzaA(H1N1)pdm09 VirusesfromPakistanin2009–2010 UzmaBashirAamir1,NazishBadar1,MuhammadRashidMehmood1,NadiaNisar1 ,Rana MuhammadSuleman1,ShehzadShaukat1,SalmanSharif1,JaleelKamran2,SyedSohailZahoorZaidi1*, BirjeesMazherKazi2,LarisaGubareva3,XiyanXu3,RebeccaGarten3,AlexanderKlimov3 1Department of Virology, Public Health Laboratories Division, National Institute of Health, Chak Shahzad, Islamabad, Pakistan, 2Public Health Laboratories Division, NationalInstituteofHealth,ChakShahzad,Islamabad,Pakistan,3InfluenzaDivision,CentersforDiseaseControl,Atlanta,Georgia,UnitedStatesofAmerica Abstract Background:Inearly2009,anovelinfluenzaA(H1N1)virusthatemergedinMexicoandUnitedStatesrapidlydisseminated worldwide.Thespread ofthisvirus causedconsiderablemorbidity withover18000 recordeddeaths.Thenewvirus was foundtobeareassortantcontaininggenesegmentsfromhuman,avianandswineinfluenzaviruses. Methods/Results:ThefirstcaseofhumaninfectionwithA(H1N1)pdm09inPakistanwasdetectedon18thJune2009.Since then,262laboratory-confirmedcaseshavebeendetectedduringvariousoutbreakswith29deaths(asof31stAugust2010). The peak of the epidemic was observed in December with over 51% of total respiratory cases positive for influenza. Representative isolates from Pakistan viruses were sequenced and analyzed antigenically. Sequence analysis of genes codingforsurfaceglycoproteinsHAandNAshowedhighdegreeofhighlevelsofsequenceidentitywithcorresponding genesofregionalvirusescirculatingSouthEastAsia.AlltestedvirusesweresensitivetoOseltamivirintheNeuraminidase Inhibitionassays. Conclusions:InfluenzaA(H1N1)pdm09virusesfromPakistanformahomogenousgroupofviruses.TheirHAgenesbelong to clade 7 and show antigenic profile similar to the vaccine strain A/California/07/2009. These isolates do not show any aminoacidchangesindicativeofhighpathogenicityandvirulence.Itisimperativetocontinuemonitoringoftheseviruses foridentificationofpotentialvariantsofhighvirulenceordrugresistance. Citation:BashirA