NEDD9 Is a Positive Regulator of Epithelial-Mesenchymal Transition and Promotes Invasion in Aggressive Breast Cancer 英文参考文献.docVIP

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NEDD9 Is a Positive Regulator of Epithelial-Mesenchymal Transition and Promotes Invasion in Aggressive Breast Cancer 英文参考文献.doc

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NEDD9 Is a Positive Regulator of Epithelial-Mesenchymal Transition and Promotes Invasion in Aggressive Breast Cancer 英文参考文献

NEDD9IsaPositiveRegulatorofEpithelial-Mesenchymal TransitionandPromotesInvasioninAggressiveBreast Cancer ChenfeiKong1,ChangqingWang2,LipingWang3,MusongMa2,ChunboNiu3,XiaoqianSun4,JuanDu1, ZhixiongDong1,ShanZhu1,JunLu4*,BaiquHuang1* 1TheInstituteofGeneticsandCytology,NortheastNormalUniversity,Changchun,People’sRepublicofChina,2TheBreastSurgery,TheTumorHospitalofJilinProvince, Changchun, People’s Republic of China, 3The Pathology Department, The Bethune Hospital of Jilin University, Changchun, People’s Republic of China, 4The Key LaboratoryofMolecularEpigeneticsofMinistryofEducation,NortheastNormalUniversity,Changchun,People’sRepublicofChina Abstract Epithelialtomesenchymaltransition(EMT)playsanimportantroleinmanybiologicalprocesses.Thelateststudiesrevealed thataggressivebreastcancer,especiallythetriple-negativebreastcancer(TNBC)subtypewasfrequentlyassociatedwith apparent EMT, but the mechanisms are still unclear. NEDD9/HEF1/Cas-L is a member of the Cas protein family and was identifiedasametastasismarkerinmultiplecancertypes.Inthisstudy,wewishedtodiscerntheroleofNEDD9inbreast cancerprogressionandtoinvestigatethemolecularmechanismbywhichNEDD9regulatesEMTandpromotesinvasionin triple-negativebreastcancer.WeshowedthatexpressionofNEDD9wasfrequentlyupregulatedinTNBCcelllines,andin aggressivebreasttumors,especiallyinTNBCsubtype.KnockdownofendogenousNEDD9reducedthemigration,invasion andproliferationofTNBCcells.Moreover,ectopicoverexpressionofNEDD9inmammaryepithelialcellsledtoastringof eventsincludingthetriggerofEMT,activationofERKsignaling,increaseofseveralEMT-inducingtranscriptionfactorsand promotionoftheirinteractionswiththeE-cadherinpromoter.Datapresentedinthisreportcontributetotheunderstanding ofthemechanismsbywhichNEDD9promotesEMT,andprovideusefulcluestotheevaluationofthepotentialofNEDD9as aresponsivemoleculartargetforTNBCchemotherapy. Citation: Kong C, Wang C, Wang L, Ma M, Niu C, et al.(2011) NEDD9 Is a Positive Regulator ofEpithelial-Mesenchymal Transition and Prom