Neural Population-Level Memory Traces in the Mouse Hippocampus 英文参考文献.docVIP

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Neural Population-Level Memory Traces in the Mouse Hippocampus 英文参考文献.doc

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Neural Population-Level Memory Traces in the Mouse Hippocampus 英文参考文献

NeuralPopulation-LevelMemoryTracesintheMouse Hippocampus GuifenChen,L.PhillipWang,JoeZ.Tsien* BrainandBehaviorDiscoveryInstituteandDepartmentofNeurology,SchoolofMedicine,MedicalCollegeofGeorgia,Augusta,Georgia,UnitedStatesofAmerica Abstract Oneofthefundamentalgoalsinneurosciencesistoelucidatetheformationandretrievalofbrain’sassociativememory tracesinreal-time.Here,wedescribereal-timeneuralensembletransientdynamicsinthemousehippocampalCA1region anddemonstratetheirrelationshipswithbehavioralperformancesduringbothlearningandrecall.Weemployedtheclassic tracefearconditioningparadigminvolvinganeutraltonefollowedbyamildfoot-shock20secondslater.Ourlarge-scale recordinganddecodingmethodsrevealedthatconditionedtoneresponsesandtone-shockassociationpatternswerenot present in CA1 during the first pairing, but emerged quickly after multiple pairings. These encoding patterns showed increased immediate-replay, correlating tightly with increased immediate-freezing during learning. Moreover, during contextual recall, these patterns reappeared in tandem six-to-fourteen times per minute, again correlating tightly with behavioralrecall.Upontracedtonerecall,whilevariousfearmemorieswereretrieved,theshocktracesexhibitedaunique recall-peakaroundthe20-secondtraceinterval,furthersignifyingthememoryoftimefortheexpectedshock.Therefore, ourstudyhasrevealedvariousreal-timeassociativememorytracesduringlearningandrecallinCA1,anddemonstratesthat real-timememorytracescanbedecodedonamoment-to-momentbasisoveranysingletrial. Citation: Chen G, Wang LP, Tsien JZ (2009) Neural Population-Level Memory Traces in the Mouse Hippocampus. PLoS ONE 4(12): e8256. doi:10.1371/ journal.pone.0008256 Editor:EhsanArabzadeh,UniversityofNewSouthWales,Australia ReceivedOctober7,2009;AcceptedNovember19,2009;PublishedDecember16,2009 Copyright: ? 2009 Chen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse,distribution,andreproductionin