Nest Making and Oxytocin Comparably Promote Wound Healing in Isolation Reared Rats 英文参考文献.docVIP

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Nest Making and Oxytocin Comparably Promote Wound Healing in Isolation Reared Rats 英文参考文献.doc

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Nest Making and Oxytocin Comparably Promote Wound Healing in Isolation Reared Rats 英文参考文献

NestMakingandOxytocinComparablyPromoteWound HealinginIsolationRearedRats AntoniaVitalo2,4,5,6,JonathanFricchione2,4,5,6,MonicaCasali2,4,5,6,8,YevgenyBerdichevsky2,5,6,8 ElizabethA.Hoge1,7,ScottL.Rauch7,10,FrancoisBerthiaume2,5,6,8,MartinL.Yarmush2,5,6,8 ,Herbert Benson3,4,9,GregoryL.Fricchione1,4,7*,JohnB.Levine1,2,4,5,6,7 , * 1DepartmentofPsychiatry,MassachusettsGeneralHospital,Boston,Massachusetts,UnitedStatesofAmerica,2DepartmentofSurgery,MassachusettsGeneralHospital, Boston,Massachusetts,UnitedStatesofAmerica,3DepartmentofMedicineServices,MassachusettsGeneralHospital,Boston,Massachusetts,UnitedStatesofAmerica, 4Benson Henry Institute for Mind Body Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America, 5Center for Engineering and Medicine,MassachusettsGeneralHospital,Boston,Massachusetts,UnitedStatesofAmerica,6ShrinersBurnsHospital,Boston,Massachusetts,UnitedStatesofAmerica, 7Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, United States of America, 8Department of Surgery, Harvard Medical School, Boston, Massachusetts, United States of America, 9Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America, 10McLean Hospital, Belmont,Massachusetts,UnitedStatesofAmerica Abstract Background:Environmentalenrichment(EE)fostersattachmentbehaviorthroughitseffectonbrainoxytocinlevelsinthe hippocampusandotherbrainregions,whichinturnmodulatethehypothalamic-pituitaryaxis(HPA).Socialisolationand otherstressorsnegativelyimpactphysicalhealingthroughtheireffectontheHPA.Therefore,wereasonedthat:1)provision ofaratEE(nestbuildingwithNestletsH)wouldimprovewoundhealinginratsundergoingstressduetoisolationrearing and2)thatoxytocinwouldhaveasimilarbeneficialeffectonwoundhealing. Methodology/PrincipalFindings:Inthefirsttwoexperiments,weprovidedisolationrearedratswitheitherEEoroxytocin andcomparedtheirwoundhealingtogrouprearedratsandisolationrearedratsthatdidnotreceiveNestletsoroxytocin. In t