Naturally Occurring PrecoreCore Region Mutations of Hepatitis B Virus Genotype C Related to Hepatocellular Carcinoma 英文参考文献.docVIP

下载本文档

2
0
约3.61万字
约 8页
2017-05-12 发布于上海
举报
版权申诉

Naturally Occurring PrecoreCore Region Mutations of Hepatitis B Virus Genotype C Related to Hepatocellular Carcinoma 英文参考文献.doc

1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
7、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

Naturally Occurring PrecoreCore Region Mutations of Hepatitis B Virus Genotype C Related to Hepatocellular Carcinoma 英文参考文献

NaturallyOccurringPrecore/CoreRegionMutationsof HepatitisBVirusGenotypeCRelatedtoHepatocellular Carcinoma Dong-WonKim.,Seoung-AeLee.,Eung-SooHwang,Yoon-HohKook,Bum-JoonKim* DepartmentofMicrobiologyandImmunology,LiverResearchInstituteandCancerResearchInstitute,CollegeofMedicine,SeoulNationalUniversity,Seoul,Korea Abstract PreviousstudieshaveprovedthepresenceofseveraldistincttypesofmutationsinhepatitisBvirus(HBV)infections,which arerelatedtotheprogressionofliverdisease.However,fewreportshavedetailedthemutationfrequenciesandmutation patternsintheprecore/core(preC/C)region,whicharebasedontheclinicalstatusandHBeAgserostatus.Ouraiminthis study is to investigate the relationships between the preC/C mutations and clinical severity or HBeAg serostatus from patientschronicallyinfectedwithHBVgenotypeC.Atotalof70Koreanchronicpatients,including35withhepatocellular carcinoma (HCC), participated in this study. HBV genotyping and precore/core mutations were analyzed by direct sequencing.AllpatientswereconfirmedtohavegenotypeCinfections.MutationsintheCregionweredistributedinanon- randommanner.Inparticular,mutationsintheMHCclassIIrestrictedregionwerefoundtobesignificantlyrelatedtoHCC. Six(preC-W28*,C-P5H/L/T,C-E83D,C-I97F/L,C-L100IandC-Q182K/*)andseventypes(preC-W28*,preC-G29D,C-D32N/H,C- E43K,C-P50A/H/Y,C-A131G/N/PandC-S181H/P)ofmutationsinthepreC/CregionwerefoundtoberelatedtoHCCandto affecttheHBeAgserostatus,respectively.Inconclusion,ourdataindicatedthatHBVvariantsintheCregion,particularlyin theMHCclassIIrestrictedregion,maycontributetotheprogressofHCCinchronicpatientsinfectedwithgenotypeC.In addition,wefoundseveraldistinctpreC/CmutationsintheKoreanchroniccohort,whichaffecttheclinicalstatusofHCC andHBeAgserostatusofpatientsinfectedwithgenotypeC. Citation:KimD-W,LeeS-A,HwangE-S,KookY-H,KimB-J(2012)NaturallyOccurringPrecore/CoreRegionMutationsofHepatitisBVirusGenotypeCRelatedto HepatocellularCarcinoma.PLoSONE7(10):e47372.doi:10.1371/journal.pone.0047372 Editor:JasonBlackard,Univers

您可能关注的文档

文档评论（0）

1234554321 + 关注: 实名认证

文档贡献者

该用户很懒，什么也没介绍

咨询Ta 进入空间

1亿VIP精品文档

更多 >

Naturally Occurring PrecoreCore Region Mutations of Hepatitis B Virus Genotype C Related to Hepatocellular Carcinoma 英文参考文献.docVIP