Nondisjunction of a Single Chromosome Leads to Breakage and Activation of DNA Damage Checkpoint in G2 英文参考文献.docVIP

NondisjunctionofaSingleChromosomeLeadsto BreakageandActivationofDNADamageCheckpointin G2 OliverQuevedo1,JonayGarc?′a-Luis1,EmilianoMatos-Perdomo1,LuisArago′n2,Fe′lixMach?′n1* 1 Unidad de Investigacio′n, Hospital Universitario Nuestra Sen?ora de Candelaria, Santa Cruz de Tenerife, Spain,2 Cell Cycle Group, MRC Clinical Sciences Centre, Imperial College London, London, United Kingdom Abstract The resolution of chromosomes during anaphase is a key step in mitosis. Failure to disjoin chromatids compromises the fidelity of chromosome inheritance and generates aneup