Odorant-Dependent Generation of Nitric Oxide in Mammalian Olfactory Sensory Neurons 英文参考文献.docVIP

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Odorant-Dependent Generation of Nitric Oxide in Mammalian Olfactory Sensory Neurons 英文参考文献.doc

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Odorant-Dependent Generation of Nitric Oxide in Mammalian Olfactory Sensory Neurons 英文参考文献

Odorant-DependentGenerationofNitricOxidein MammalianOlfactorySensoryNeurons DanielaBrunert1,3,StefanKurtenbach1,SonnurIsik2,HeikeBenecke1,Gu¨nterGisselmann1 ,Wolfgang Schuhmann2,3,HannsHatt1,3,ChristianH.Wetzel1,3 * 1Lehrstuhl fu¨r Zellphysiologie, Ruhr-Universita¨t Bochum, Bochum, Germany, 2Lehrstuhl fu¨r Analytische Chemie, AG Elektroanalytik und Sensorik, Ruhr-Universita¨t Bochum,Bochum,Germany,3InternationalGraduateSchoolofNeuroscience,Ruhr-Universita¨t Bochum,Bochum,Germany Abstract The gaseous signalling molecule nitric oxide (NO) is involved in various physiological processes including regulation of bloodpressure,immunocytotoxicityandneurotransmission.Inthemammalianolfactorybulb(OB),NOplaysaroleinthe formation of olfactory memory evoked by pheromones as well as conventional odorants. While NO generated by the neuronalisoformofNOsynthase(nNOS)regulatesneurogenesisintheolfactoryepithelium,NOhasnotbeenimplicatedin olfactorysignaltransduction.WenowshowtheexpressionandfunctionoftheendothelialisoformofNOsynthase(eNOS) inmatureolfactorysensoryneurons(OSNs)ofadultmice.UsingNO-sensitivemicroelectrodes,weshowthatstimulation liberates NO from isolated wild-type OSNs, but not from OSNs of eNOS deficient mice. Integrated electrophysiological recordings(electro-olfactogramsorEOGs)fromtheolfactoryepitheliumofthesemiceshowthatNOplaysasignificantrole inmodulatingadaptation.EvidenceforthepresenceofeNOSinmaturemammalianOSNsanditsinvolvementinodorant adaptationimplicatesNOasanimportantnewelementinvolvedinolfactorysignaltransduction.Asadiffusiblemessenger, NOcouldalsohaveadditionalfunctionsrelatedtocrossadaptation,regeneration,andmaintenanceofMOEhomeostasis. Citation:BrunertD,KurtenbachS,IsikS,BeneckeH,GisselmannG,etal.(2009)Odorant-DependentGenerationofNitricOxideinMammalianOlfactorySensory Neurons.PLoSONE4(5):e5499.doi:10.1371/journal.pone.0005499 Editor:HuibertD.Mansvelder,VrijeUniversiteitAmsterdam,Netherlands ReceivedAugust26,2008;AcceptedApril15,2009;PublishedMay11,20