Of Mice, Birds, and Men The Mouse Ultrasonic Song System Has Some Features Similar to Humans and Song-Learning Birds 英文参考文献.docVIP
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Of Mice, Birds, and Men The Mouse Ultrasonic Song System Has Some Features Similar to Humans and Song-Learning Birds 英文参考文献
OfMice,Birds,andMen:TheMouseUltrasonicSong
SystemHasSomeFeaturesSimilartoHumansandSong-
LearningBirds
GustavoArriaga1*,EricP.Zhou1,2,ErichD.Jarvis1*
1DepartmentofNeurobiology,HowardHughesMedicalInstitute,DukeUniversityMedicalCenter,Durham,NorthCarolina,UnitedStatesofAmerica,2TulaneUniversity
SchoolofMedicine,NewOrleans,Louisiana,UnitedStatesofAmerica
Abstract
Humansandsong-learningbirdscommunicateacousticallyusinglearnedvocalizations.Thecharacteristicfeaturesofthis
social communication behavior include vocal control by forebrain motor areas, a direct cortical projection to brainstem
vocalmotorneurons,anddependenceonauditoryfeedbacktodevelopandmaintainlearnedvocalizations.Thesefeatures
havesofarnotbeenfoundincloselyrelatedprimateandavianspeciesthatdonotlearnvocalizations.Malemiceproduce
courtshipultrasonicvocalizationswithacousticfeaturessimilartosongsofsong-learningbirds.However,itisassumedthat
micelackaforebrainsystemforvocalmodificationandthattheirultrasonicvocalizationsareinnate.Hereweinvestigated
themousesongsystemanddiscoveredthatitincludesamotorcortexregionactiveduringsinging,thatprojectsdirectlyto
brainstemvocalmotorneuronsandisnecessaryforkeepingsongmorestereotypedandonpitch.Wealsodiscoveredthat
malemicedependonauditoryfeedbacktomaintainsomeultrasonicsongfeatures,andthatsub-strainswithdifferencesin
theirsongscanmatcheachother’spitchwhencross-housedundercompetitivesocialconditions.Weconcludethatmale
micehavesomelimitedvocalmodificationabilitieswithatleastsomeneuroanatomicalfeaturesthoughttobeuniqueto
humansandsong-learningbirds.Toexplainourfindings,weproposeacontinuumhypothesisofvocallearning.
Citation:ArriagaG,ZhouEP,JarvisED(2012)OfMice,Birds,andMen:TheMouseUltrasonicSongSystemHasSomeFeaturesSimilartoHumansandSong-
LearningBirds.PLoSONE7(10):e46610.doi:10.1371/journal.pone.0046610
Editor:CharlesR.Larson,NorthwesternUniversity,UnitedStatesofAmerica
ReceivedMay4,2012;AcceptedSeptember6,2012;PublishedOctober10,2012
Copyright: ? 2012 Arriaga et al. This is an
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