Offset of pharmacodynamic effects and safety of remifentanil in intensive care unit patients with various degrees of renal impairment 英文参考文献.docVIP

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Offset of pharmacodynamic effects and safety of remifentanil in intensive care unit patients with various degrees of renal impairment 英文参考文献.doc

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Offset of pharmacodynamic effects and safety of remifentanil in intensive care unit patients with various degrees of renal impairment 英文参考文献

Available online /content/8/1/R21 Open Access Research Offset of pharmacodynamic effects and safety of remifentanil in intensive care unit patients with various degrees of renal impairment Des Breen1, Alexander Wilmer2, Andrew Bodenham3, Vagn Bach4, Jan Bonde5, Paul Kessler6, Sven Albrecht7 and Soraya Shaikh8 1Consultant in Anaesthesia and Intensive Care, ICU, Royal Hallamshire Hospital, Sheffield, UK 2Associate Professor of Medicine, MICU, UZ Gasthuisberg, Leuven, Belgium 3Consultant in Anaesthesia and Intensive Care, ICU, Leeds General Infirmary, Leeds, UK 4Director of Intensive Care, Hillerod Syngehus, Hillerod, Denmark 5Consultant in Intensive Care, Amtssygehuset i Herlev, Herlev, Denmark 6Assistant Professor of Anaesthesiology, ICU, J-W Goethe Universitat, Klinik fuer Anaesthesiologie, Frankfurt, Germany 7Professor and Vice Chairman, ICU, Universitat Erlangen-Nurnberg, Klinik fur Anaesthesiologie, Erlangen, Germany 8Global Study Manager, GlaxoSmithKline RD, Greenford, UK Correspondence: Des Breen, des.breen@ Received: 2 October 2003 Accepted: 16 October 2003 Published: 21 November 2003 Critical Care 2004, 8:R21-R30 (DOI 10.1186/cc2399) This article is online at /content/8/1/R21 ? 2004 Breen et al., licensee BioMed Central Ltd (Print ISSN 1364-8535; Online ISSN 1466-609X). This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the articles original URL. Abstract Introduction This open label, multicentre study was conducted to assess the times to offset of the pharmacodynamic effects and the safety of remifentanil in patients with varying degrees of renal impairment requiring intensive care. Methods A total of 40 patients, who were aged 18 years or older and had normal/mildly impaired renal function (estimated creatinine clearance ≥50 ml/min; n = 10) or moderate/severe renal impairment (estimated creatinine clearance 50 ml